p21 RAS Protein

Preferred Label : p21 RAS Protein;

NCIt synonyms : p21 RAS Family Protein; p21; p21(RAS); Transforming Protein p21; p21ras;

NCIt definition : Cellular protein encoded by the RAS genes. The protein has intrinsic GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia.;

Details

Origin ID

C17388;

UMLS CUI

C0080058;

Automatic exact mappings (from CISMeF team)
- Cyclin-dependent kinase inhibitor 1a [OMIM gene]
- Hras protooncogene, gtpase [OMIM gene]
- Oncogene protein P21, RAS (substance) [SNOMED CT concept]
- Proto-Oncogene proteins p21(ras) [MeSH Descriptor]
- Transcription elongation factor a-like 1 [OMIM gene]
- cyclin dependent kinase inhibitor 1A [ORDO Gene]
- oncogene protein p21(ras) [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Proto-Oncogene proteins p21(ras) [MeSH concept]
- Proto-Oncogene proteins p21(ras) [MeSH Descriptor]
concept_is_in_subset
- Pediatric Oncology Target Genes/Proteins Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- RAS Family Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_biochemical_function
- GTPase [NCIt concept]
gene_product_has_gene_product_variant
- Activating RAS Q61X [NCIt concept]
- HRAS NP_005334.1:p.G12D [NCIt concept]
- HRAS NP_005334.1:p.G12V [NCIt concept]
- HRAS NP_005334.1:p.G12X [NCIt concept]
- HRAS NP_005334.1:p.G13X [NCIt concept]
- HRAS NP_005334.1:p.Q61X [NCIt concept]
- HRAS Protein Variant [NCIt concept]
- KRAS NP_004976.2:p.A146T [NCIt concept]
- KRAS NP_004976.2:p.A146X [NCIt concept]
- KRAS NP_004976.2:p.A59X [NCIt concept]
- KRAS NP_004976.2:p.G12A [NCIt concept]
- KRAS NP_004976.2:p.G12C [NCIt concept]
- KRAS NP_004976.2:p.G12D [NCIt concept]
- KRAS NP_004976.2:p.G12E [NCIt concept]
- KRAS NP_004976.2:p.G12F [NCIt concept]
- KRAS NP_004976.2:p.G12I [NCIt concept]
- KRAS NP_004976.2:p.G12L [NCIt concept]
- KRAS NP_004976.2:p.G12N [NCIt concept]
- KRAS NP_004976.2:p.G12R [NCIt concept]
- KRAS NP_004976.2:p.G12S [NCIt concept]
- KRAS NP_004976.2:p.G12V [NCIt concept]
- KRAS NP_004976.2:p.G12W [NCIt concept]
- KRAS NP_004976.2:p.G12X [NCIt concept]
- KRAS NP_004976.2:p.G12Y [NCIt concept]
- KRAS NP_004976.2:p.G13A [NCIt concept]
- KRAS NP_004976.2:p.G13C [NCIt concept]
- KRAS NP_004976.2:p.G13D [NCIt concept]
- KRAS NP_004976.2:p.G13E [NCIt concept]
- KRAS NP_004976.2:p.G13N [NCIt concept]
- KRAS NP_004976.2:p.G13R [NCIt concept]
- KRAS NP_004976.2:p.G13S [NCIt concept]
- KRAS NP_004976.2:p.G13V [NCIt concept]
- KRAS NP_004976.2:p.G13X [NCIt concept]
- KRAS NP_004976.2:p.K117X [NCIt concept]
- KRAS NP_004976.2:p.Q61D [NCIt concept]
- KRAS NP_004976.2:p.Q61E [NCIt concept]
- KRAS NP_004976.2:p.Q61H [NCIt concept]
- KRAS NP_004976.2:p.Q61K [NCIt concept]
- KRAS NP_004976.2:p.Q61L [NCIt concept]
- KRAS NP_004976.2:p.Q61P [NCIt concept]
- KRAS NP_004976.2:p.Q61R [NCIt concept]
- KRAS NP_004976.2:p.Q61X [NCIt concept]
- KRAS Protein Variant [NCIt concept]
- NRAS NP_002515.1:p.G12A [NCIt concept]
- NRAS NP_002515.1:p.G12C [NCIt concept]
- NRAS NP_002515.1:p.G12D [NCIt concept]
- NRAS NP_002515.1:p.G12R [NCIt concept]
- NRAS NP_002515.1:p.G12S [NCIt concept]
- NRAS NP_002515.1:p.G12V [NCIt concept]
- NRAS NP_002515.1:p.G12X [NCIt concept]
- NRAS NP_002515.1:p.G13D [NCIt concept]
- NRAS NP_002515.1:p.G13R [NCIt concept]
- NRAS NP_002515.1:p.G13S [NCIt concept]
- NRAS NP_002515.1:p.G13V [NCIt concept]
- NRAS NP_002515.1:p.G13X [NCIt concept]
- NRAS NP_002515.1:p.Q61E [NCIt concept]
- NRAS NP_002515.1:p.Q61H [NCIt concept]
- NRAS NP_002515.1:p.Q61K [NCIt concept]
- NRAS NP_002515.1:p.Q61L [NCIt concept]
- NRAS NP_002515.1:p.Q61P [NCIt concept]
- NRAS NP_002515.1:p.Q61R [NCIt concept]
- NRAS NP_002515.1:p.Q61X [NCIt concept]
- NRAS Protein Variant [NCIt concept]
- RAS Family Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- GTP Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- GTP Binding [NCIt concept]
- Hydrolysis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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