Preferred Label : Activating RAS Q61X;
NCIt synonyms : Activating RAS Family Q61 Mutation; Activating RASQ61 Mutation; Activating RAS Gln61 Mutation; Activating RAS Family Gln61 Mutation; Activating RAS Family Codon 61 Mutation; Activating RAS Gln61Xxx;
NCIt related terms : Activating RAS Q61 Mutation;
NCIt definition : A change in the amino acid residue at position 61 of a RAS family (HRAS, KRAS or NRAS)
protein where the glutamine is replaced by another amino acid and the encoded GTPase
is resistant to GTP hydrolysis, which results in constitutive activation of its activity
and downstream pathways.;
NCI Metathesaurus CUI : CL1647555;
Origin ID : C177785;
UMLS CUI : C5554620;
Semantic type(s)
- concept_is_in_subset
- gene_product_variant_of_gene_product
