Transmembrane Protein PVRIG

Preferred Label : Transmembrane Protein PVRIG;

NCIt synonyms : Poliovirus Receptor Related Immunoglobulin Domain Containing Protein; CD 112R; CD112R; Nectin-2 Receptor; CD112 Receptor; Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein;

NCIt definition : Transmembrane protein PVRIG (326 aa, 34 kDa) is encoded by the human PVRIG gene. This protein plays a role in the inhibition of T-cell-mediated immunity.;

NCIt note : Transmembrane protein PVRIG competes with CD226 antigen for binding to nectin-2. (UniProt);

NCI Metathesaurus CUI : CL935851;

Details

Origin ID

C156803;

UMLS CUI

C4723729;

Automatic exact mappings (from CISMeF team)
- Nectins [MeSH Descriptor]
- PVR related immunoglobulin domain containing [HGNC gene]
- Poliovirus receptor-related immunoglobulin domain-containing protein [OMIM gene]
OMIM relation
- Poliovirus receptor-related immunoglobulin domain-containing protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- PVRIG Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- CD8-Positive T-Lymphocyte [NCIt concept]
- Natural Killer Cell [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Immunosuppressive Effect [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Lymphocyte Activation [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-PVRIG Monoclonal Antibody COM701 [NCIt concept]
- Anti-PVRIG Monoclonal Antibody GSK4381562 [NCIt concept]
- Anti-PVRIG Monoclonal Antibody JS009 [NCIt concept]
- Anti-PVRIG Monoclonal Antibody NM1F [NCIt concept]
- Anti-TIGIT/Anti-PVRIG Bispecific Antibody PM1009 [NCIt concept]
- Anti-TIGIT/Anti-PVRIG Bispecific Antibody SIM0348 [NCIt concept]

Keyword's position in hierarchy(ies) :

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