NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody against poliovirus receptor-related
immunoglobulin (PVRIG; PVR related immunoglobulin domain containing protein; CD112R),
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
anti-PVRIG monoclonal antibody NM1F targets and binds to PVRIG expressed on cytotoxic
T-lymphocytes (CTLs) and natural killer (NK) cells within the tumor microenvironment
(TME). This blocks the interaction of PVRIG with its ligand nectin cell adhesion molecule
2 (poliovirus receptor-related 2; PVRL2; CD112), which is overexpressed on a variety
of tumor cell types. Inhibiting the activation of PVRIG abrogates the PVRIG-induced
inhibition of T-lymphocyte and NK cell activation. This activates CTLs and NK cells,
enhances anti-tumor responses and immune-mediated tumor cell killing, and inhibits
tumor cell proliferation. PVRIG, a member of the B7/CD28 family and an immune checkpoint
receptor that, upon activation, negatively regulates the activation of various immune
cells. It plays a key role in immunosuppression.;
Semantic type(s)