NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against poliovirus receptor-related
immunoglobulin (PVRIG; PVR Related Immunoglobulin Domain Containing Protein; CD112R),
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
anti-PVRIG monoclonal antibody GSK4381562 targets and binds to PVRIG expressed on
cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells within the tumor microenvironment
(TME), thereby blocking the interaction of PVRIG with its ligand nectin cell adhesion
molecule 2 (poliovirus receptor-related 2; PVRL2; CD112), which is overexpressed on
a variety of tumor cell types. This abrogates the PVRIG-mediated inhibition of T-lymphocyte
and NK cell activation. This activates CTLs and NK cells, enhances anti-tumor responses
and immune-mediated tumor cell killing, and inhibits tumor cell proliferation. PVRIG,
a member of the B7/CD28 family and an immune checkpoint receptor, negatively regulates
the activation of various immune cells upon activation and plays a key role in immunosuppression.;
Molecule name : GSK-4381562; SRF-813; SRF 813; GSK 4381562;
Semantic type(s)