NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against poliovirus receptor-related
immunoglobulin (PVRIG; PVR Related Immunoglobulin Domain Containing Protein; CD112R),
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
remzistotug targets and binds to PVRIG expressed on cytotoxic T-lymphocytes (CTLs)
and natural killer (NK) cells within the tumor microenvironment (TME), thereby blocking
the interaction of PVRIG with its ligand nectin cell adhesion molecule 2 (poliovirus
receptor-related 2; PVRL2; CD112), which is overexpressed on a variety of tumor cell
types. This abrogates the PVRIG-mediated inhibition of T-lymphocyte and NK cell activation.
This activates CTLs and NK cells, enhances anti-tumor responses and immune-mediated
tumor cell killing, and inhibits tumor cell proliferation. PVRIG, a member of the
B7/CD28 family and an immune checkpoint receptor, negatively regulates the activation
of various immune cells upon activation and plays a key role in immunosuppression.;
UNII : 4U47PC3GYR;
CAS number : 2920425-39-2;
Molecule name : GSK-4381562; SRF-813; SRF 813; GSK 4381562;
Semantic type(s)