Preferred Label : Anti-PVRIG Monoclonal Antibody COM701;
NCIt synonyms : Anti-poliovirus Receptor-related Immunoglobulin COM701; PVRIG Inhibitor COM701;
NCIt related terms : COM-701;
NCIt definition : A humanized, hybridoma monoclonal antibody against the poliovirus receptor-related
immunoglobulin (PVRIG; PVR Related Immunoglobulin Domain Containing Protein; CD112R),
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
anti-PVRIG monoclonal antibody COM701 targets and binds to PVRIG expressed on cytotoxic
T-lymphocytes (CTLs) and natural killer (NK) cells within the tumor microenvironment
(TME). This blocks the interaction of PVRIG with its ligand nectin cell adhesion molecule
2 (poliovirus receptor-related 2; PVRL2; CD112), which is overexpressed on a variety
of tumor cell types. Inhibiting the activation of PVRIG, abrogates the PVRIG-induced
inhibition of T-lymphocyte and NK cell activation. This activates CTLs and NK cells,
enhances anti-tumor responses and immune-mediated tumor cell killing, and inhibits
tumor cell proliferation. PVRIG, a member of the B7/CD28 family and immune checkpoint
receptor that, upon activation, negatively regulates the activation of various immune
cells. It plays a key role in immunosuppression.;
UNII : IAY02XUV7L;
CAS number : 2253186-93-3;
Molecule name : COM-701; COM 701;
NCI Metathesaurus CUI : CL935797;
Origin ID : C156791;
UMLS CUI : C4745069;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
