Negative Regulation of Lymphocyte Activation

Preferred Label : Negative Regulation of Lymphocyte Activation;

NCIt synonyms : Lymphocyte Suppression;

NCIt definition : Lymphocyte Suppression involves interference with, or restraint of, the production and activity of lymphocytes. Formed in lymphoid tissue, lymphocytes are white blood cells that can generally be classified as either T- or B-cells. T-lymphocytes provide cell-mediated immunity, while B-lymphocytes produce antibodies that provide humoral immunity. Suppression decreases the ability of lymphocytes to mount an immune response to invading substances.;

Details

Origin ID

C40846;

UMLS CUI

C1518065;

Automatic exact mappings (from CISMeF team)
- negative regulation of lymphocyte activation [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- negative regulation of lymphocyte activation [GO term]
biological_process_has_initiator_chemical_or_drug
- Antigen [NCIt concept]
biological_process_involves_gene_product
- CTLA-4 Ligand [NCIt concept]
- T-Cell Immunoreceptor with Ig and ITIM Domains [NCIt concept]
- Transmembrane Protein PVRIG [NCIt concept]
- V-Set Domain-Containing T-Cell Activation Inhibitor 1 [NCIt concept]
- V-Set and Immunoglobulin Domain-Containing Protein 4 [NCIt concept]
biological_process_is_part_of_process
- Immune Response Process [NCIt concept]
process_involves_gene
- PVRIG Gene [NCIt concept]
- PVRIG wt Allele [NCIt concept]
- TIGIT Gene [NCIt concept]
- TIGIT wt Allele [NCIt concept]
- VSIG4 Gene [NCIt concept]
- VSIG4 wt Allele [NCIt concept]
- VTCN1 Gene [NCIt concept]
- VTCN1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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