Dabrafenib Mesylate

Preferred Label : Dabrafenib Mesylate;

NCIt synonyms : Dabrafenib Methanesulfonate; GSK2118436 Methane Sulfonate Salt;

NCIt definition : The mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.;

UNII : B6DC89I63E;

InChIKey : YKGMKSIHIVVYKY-UHFFFAOYSA-N;

CAS number : 1195768-06-9;

Drug name : Tafinlar;

Molecule name : GSK2118436B;

Details

Origin ID

C128059;

UMLS CUI

C3644554;

Currated CISMeF NLP mapping
- Dabrafenib mesilate (substance) [SNOMED CT concept]
- Dabrafenib mesylate [SMS substance]
- dabrafenib mesilate [Substance BNPC]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dabrafenib mesilate (substance) [SNOMED CT concept]
- dabrafenib mesilate [Substance BNPC]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Dabrafenib [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
is_component_of_chemotherapy_regimen
- Dabrafenib Regimen [NCIt concept]
- Dabrafenib/Pembrolizumab/Trametinib Regimen [NCIt concept]
is_salt_form_of
- Dabrafenib [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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