" /> Dabrafenib Mesylate - CISMeF





Preferred Label : Dabrafenib Mesylate;

NCIt synonyms : Dabrafenib Methanesulfonate; GSK2118436 Methane Sulfonate Salt;

NCIt definition : The mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.;

UNII : B6DC89I63E;

InChIKey : YKGMKSIHIVVYKY-UHFFFAOYSA-N;

CAS number : 1195768-06-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1195768-06-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Tafinlar;

Molecule name : GSK2118436B;

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12/05/2024


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