Dabrafenib - CISMeF

Preferred Label : Dabrafenib;

NCIt synonyms : BRAF Inhibitor GSK2118436; Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-;

NCIt definition : An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.;

UNII : QGP4HA4G1B;

InChIKey : BFSMGDJOXZAERB-UHFFFAOYSA-N;

CAS number : 1195765-45-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1195765-45-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : GSK-2118436; GSK-2118436A;

Chemical formula : C23H20F3N5O2S2;

Codes from synonyms : 131;

Details

Origin ID

C82386;

UMLS CUI

C3467876;

Automatic exact mappings (from CISMeF team)
- Dabrafenib [ICD-11 Extension code]
- GSK 2118436 [MeSH concept]
- dabrafenib [ATC Code]
Currated CISMeF NLP mapping
- Dabrafenib (substance) [SNOMED CT concept]
- dabrafenib [MeSH Supplementary Concept]
- dabrafenib [MeSH concept]
See also inter- (CISMeF)
- Product containing dabrafenib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dabrafenib (substance) [SNOMED CT concept]
- Product containing dabrafenib (medicinal product) [SNOMED CT concept]
- dabrafenib [MeSH Supplementary Concept]
- dabrafenib [MeSH concept]
- dabrafenib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Dabrafenib Mesylate [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
is_component_of_chemotherapy_regimen
- Dabrafenib-Trametinib-Cetuximab Regimen [NCIt concept]
- Dabrafenib-Trametinib-Panitumumab Regimen [NCIt concept]
- Dabrafenib/Trametinib Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Dabrafenib Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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