NCIt definition : An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic
activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which
may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf
belongs to the raf/mil family of serine/threonine protein kinases and plays a role
in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated
due to BRAF gene mutations.;
UNII : QGP4HA4G1B;
InChIKey : BFSMGDJOXZAERB-UHFFFAOYSA-N;
CAS number : 1195765-45-7;
Molecule name : GSK-2118436; GSK-2118436A; GSK 2118436A; GSK 2118436;