" /> Dabrafenib - CISMeF





Preferred Label : Dabrafenib;

NCIt synonyms : BRAF Inhibitor GSK2118436; Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-;

NCIt definition : An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.;

UNII : QGP4HA4G1B;

InChIKey : BFSMGDJOXZAERB-UHFFFAOYSA-N;

CAS number : 1195765-45-7;

Molecule name : GSK-2118436; GSK-2118436A; GSK 2118436A; GSK 2118436;

Chemical formula : C23H20F3N5O2S2;

Codes from synonyms : 131;

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Keyword's position in hierarchy(ies) : arborescence

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31/05/2025


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