cilastatin - CISMeF

Preferred Label : cilastatin;

MeSH definition : A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.;

CISMeF synonym : 81129-83-1 (Cilastatin sodium); 0791, MK;

MeSH hyponym : cilastatin sodium; MK 0791; MK-791; MK 791; MK791; MK0791; Sodium, Cilastatin; Cilastatin Monosodium Salt; Monosodium Salt, Cilastatin; Salt, Cilastatin Monosodium;

MeSH CAS label : 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-;

MeSH Related Number : cilastatin sodium; 81129-83-1 (mono-Na salt); 82009-34-5 (Cilastatin); 5428WXZ74M;

Registry Number MeSH : 82009-34-5;

Related CAS MeSH : 5428WXZ74M (Cilastatin sodium);

Wikipedia link : https://en.wikipedia.org/wiki/Cilastatin;

Codes EINECS : 279-875-8;

Is substance : O;

UNII : 141A6AMN38;

InChIKey : DHSUYTOATWAVLW-WFVMDLQDSA-N;

Details

Origin ID

D015377;

UMLS CUI

C0008777;

ATC code(s)
- imipenem and cilastatin [ATC Code]
- imipenem, cilastatin and relebactam [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Cilastatin Sodium [NCIt concept]
CISMeF manual mappings
- cilastatin [Substance BNPC]
Currated CISMeF NLP mapping
- Cilastatin [LOINC component]
- Cilastatin [SMS substance]
- Cilastatin [NCIt concept]
- Cilastatin (substance) [SNOMED CT concept]
- cilastatin [SNOMED Notion]
Manual BTNT mappings - CISMeF
- Cilastatin Sodium [NCIt concept]
Pharmacological action(s)
- protease inhibitors [MeSH Descriptor]
Record concept(s)
- MK 0791 [MeSH concept]
- cilastatin [MeSH concept]
- cilastatin sodium [MeSH concept]
Related MeSH Supplementary Concept(s)
- N-acetylcilastatin [MeSH Supplementary Concept]
- imipenem, cilastatin and relebactam [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing cilastatin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cilastatin [NCIt concept]
- Cilastatin [LOINC component]
- Cilastatin (substance) [SNOMED CT concept]
- Product containing cilastatin (medicinal product) [SNOMED CT concept]
- cilastatin [Substance BNPC]
- cilastatin [SNOMED Notion]

Keyword's position in hierarchy(ies) :

Main resources

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