NCIt definition : The sodium salt form of cilastatin, a renal dehydropeptidase inhibitor, that can be
used to inhibit the activity of renal dehydropeptidase. Upon administration of cilastatin
sodium, cilastatin targets, binds to and inhibits the activity of renal dehydropeptidase.
This reduces the breakdown of drugs, such as the broad spectrum beta-lactam carbapenem
imipenem, by renal dehydropeptidase, and thereby increases the activity and therapeutic
effect of such drugs that would otherwise be metabolized by renal dehydropeptidase.;