Cilastatin, Imipenem Drug Combination

Preferred Label : Cilastatin, Imipenem Drug Combination;

MeSH definition : Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent.;

MeSH synonym : Imipenem - Cilastatin; Imipenem-Cilastatin; Imipenem Cilastatin; Cilastatin, Imipenem;

MeSH hyponym : MK 0787 MK 0791 mixture; MK 787-MK 791 mixture; MK 787 MK 791 mixture; Imipenem Cilastatin, Sodium Salt; Imipenem - Cilastatin Sodium; Imipenem-Cilastatin Sodium; Imipenem Cilastatin Sodium;

MeSH Related Number : 85960-17-4 (Na salt);

Registry Number MeSH : 92309-29-0;

Wikipedia link : https://en.wikipedia.org/wiki/Imipenem-cilastatin;

Details

Origin ID

D000077728;

UMLS CUI

C0071972;

ATC code(s)
- imipenem and cilastatin [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Imipenem and cilastatin [ICD-11 Extension code]
- Imipenem-Cilastatin Sodium [NCIt concept]
Currated CISMeF NLP mapping
- Imipenem Cilastatin [Pharmacological Root]
- Imipenem+Cilastatin [LOINC component]
- Product containing cilastatin and imipenem (medicinal product) [SNOMED CT concept]
Pharmacological action(s)
- anti-bacterial agents [MeSH Descriptor]
- protease inhibitors [MeSH Descriptor]
Record concept(s)
- MK 0787-MK 0791 mixture [MeSH concept]
- cilastatin, imipenem drug combination [MeSH concept]
- imipenem-cilastatin, sodium salt [MeSH concept]
- primaxin [MeSH concept]
- thienam [MeSH concept]
- tienam 500 [MeSH concept]
- zienam [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- Imipenem Cilastatin [Pharmacological Root]
UMLS correspondences (same concept)
- Imipenem Cilastatin [Pharmacological Root]
- Imipenem+Cilastatin [LOINC component]
- Product containing cilastatin and imipenem (medicinal product) [SNOMED CT concept]
- imipenem and cilastatin [ATC Code]
Validated automatic mappings to BTNT
- imipenem and cilastatin [ATC Code]

Keyword's position in hierarchy(ies) :

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