Imipenem-Cilastatin Sodium

Preferred Label : Imipenem-Cilastatin Sodium;

NCIt synonyms : Imipenem/Cilastatin Sodium;

NCIt related terms : Primaxin;

NCIt definition : A parenteral antibiotic preparation containing imipenem and cilastatin sodium with bactericidal activity. Imipenem, a broad spectrum beta-lactam antibiotic, binds to penicillin-binding proteins (PBP) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. Cilastatin sodium is added to reduce breakdown of imipenem by kidney dehydropeptidase. This agent is effective against both gram positive and negative bacteria and is often used in treating severe infections caused by multiresistant organisms.;

Drug name : Primaxin;

Codes from synonyms : NSC0717864;

Details

Origin ID

C2338;

UMLS CUI

C0145617;

Automatic exact mappings (from CISMeF team)
- Cilastatin, Imipenem Drug Combination [MeSH Descriptor]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- imipenem with cilastin sodium [SNOMED Notion]
- imipenem-cilastatin, sodium salt [MeSH concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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