mycophenolic acid

Preferred Label : mycophenolic acid;

MeSH definition : An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301); Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.;

CISMeF synonym : acid, mycophenolic;

DeCS synonym : Mycophenolate Mofetil; Myfortic; Cellcept; Mycophenolate Mofetil Hydrochloride; RS 61443;

MeSH hyponym : Mofetil, Mycophenolate; Mycophenolic Acid Morpholinoethyl Ester; Sodium Mycophenolate; Mycophenolate, Sodium; Mofetil Hydrochloride, Mycophenolate; RS-61443; RS61443;

MeSH CAS label : -Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-;

MeSH Related Number : 24280-93-1 (Mycophenolic acid); 128794-94-5 (mycophenolate mofetil); 9242ECW6R0; UXH81S8ZVB; WX877SQI1G;

Registry Number MeSH : 24280-93-1;

Wikipedia link : https://en.wikipedia.org/wiki/Mycophenolic acid;

Codes EINECS : 246-119-3;

Is substance : O;

UNII : HU9DX48N0T;

InChIKey : HPNSFSBZBAHARI-RUDMXATFSA-N;

Details

Origin ID

D009173;

UMLS CUI

C0026933;

ATC code(s)
- mycophenolic acid [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- Measurement of mycophenolic acid (procedure) [SNOMED CT concept]
- mycophenolic acid [Substance BNPC]
False automatic mappings
- Acute purulent meningitis (disorder) [SNOMED CT concept]
- Microscopic polyangiitis [ORDO Disease]
- Microscopic polyangiitis [ICD-11 Sub-sub category]
- medroxyprogesterone acetate [Substance BNPC]
Pharmacological action(s)
- antibiotics, antineoplastic [MeSH Descriptor]
- antibiotics, antitubercular [MeSH Descriptor]
- enzyme inhibitors [MeSH Descriptor]
Record concept(s)
- Mycophenolate Sodium [MeSH concept]
- RS 61443 [MeSH concept]
- cellcept [MeSH concept]
- mycophenolate mofetil [MeSH concept]
- mycophenolate mofetil hydrochloride [MeSH concept]
- mycophenolic acid [MeSH concept]
- myfortic [MeSH concept]
Related MeSH Supplementary Concept(s)
- 1,3-dipalmitoyl-2-mycophenoloyl glycerol [MeSH Supplementary Concept]
- 2,3,5-trihydroxy-5-(propylcarbamoyl)cyclohexyl 6-(4-ethoxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate [MeSH Supplementary Concept]
- 6-((2E,6E)-3,7,11-trimethyldedoca-2,6,10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one [MeSH Supplementary Concept]
- 6-((2E,6E)-3,7-dimethyldeca-2,6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one [MeSH Supplementary Concept]
- C2-mycophenolic adenine dinucleotide [MeSH Supplementary Concept]
- C4-mycophenolic adenine dinucleotide [MeSH Supplementary Concept]
- C6-mycophenolic adenine dinucleotide [MeSH Supplementary Concept]
- F01 1358A [MeSH Supplementary Concept]
- F01 1358B [MeSH Supplementary Concept]
- F13459 [MeSH Supplementary Concept]
- beta-methylene-mycophenolic adenine dinucleotide [MeSH Supplementary Concept]
- carbamoyl mycophenolic acid ethyl ester [MeSH Supplementary Concept]
- dextran T70-mycophenolic acid conjugate [MeSH Supplementary Concept]
- ethyl O-(N-(4-carboxyphenyl)carbamoyl)mycophenolate [MeSH Supplementary Concept]
- euparvic acid [MeSH Supplementary Concept]
- mycophenolic acid glucuronide [MeSH Supplementary Concept]
- mycophenolic adenine dinucleotide [MeSH Supplementary Concept]
- penicacid A [MeSH Supplementary Concept]
- penicacid B [MeSH Supplementary Concept]
- penicacid C [MeSH Supplementary Concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Mycophenolic Acid [NCIt concept]
- Mycophenolic acid (substance) [SNOMED CT concept]
- Product containing mycophenolic acid (medicinal product) [SNOMED CT concept]
- mycophenolic acid [ATC Code]
- mycophenolic acid [Substance BNPC]
Validated automatic mappings to BTNT
- Mycophenolate sodium [SMS substance]
- Mycophenolate sodium (substance) [SNOMED CT concept]
- mycophenolic acid [ATC Code]

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