Preferred Label : fibrinogen;

MeSH definition : Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.;

MeSH synonym : blood coagulation factor i; coagulation factor i; factor i, coagulation; factor i;

CISMeF synonym : i, coagulation factor;

MeSH hyponym : gamma-Fibrinogen; gamma Fibrinogen;

MeSH CAS label : fibrinogens;

Registry Number MeSH : 9001-32-5;

MeSH annotation : a blood coag factor: do not confuse X ref FACTOR I with COMPLEMENT FACTOR I; a blood coag factor: do not confuse entry term FACTOR I with COMPLEMENT FACTOR I;

Wikipedia link : https://en.wikipedia.org/wiki/Fibrinogen;

Codes EINECS : 232-598-6;

Is substance : O;

Details


Main resources

You can consult :

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

https://ansm.sante.fr/actualites/fibrinogene-humain-lansm-a-elabore-un-guide-pratique-pour-favoriser-le-bon-usage-des-produits-disponibles
2023
false
false
false
France
French
drug compounding
drug storage
guidelines for drug use
fibrinogen
human fibrinogen
Fibrinogen Human
Product containing only human fibrinogen (medicinal product)
fibrinogen

---
https://www.has-sante.fr/jcms/p_3331596/fr/artiss-composant-1-solution-de-proteines-pour-colle-fibrinogene-humain-ap-hemostatiques-locaux-en-association
2022
France
evaluation of the transparency committee
coagulation factor i
homo sapiens
glue
asteraceae
fibrinogen
Proteins
Proteins
solutions
proteins
humans
solution, nos
Solutions
protein, nos

---
https://has-sante.fr/jcms/p_3243406/fr/veraseal-fibrinogene-humain-80-ui/ml-et-thrombine-humaine-500-ui/ml
2021
false
false
false
France
French
evaluation of the transparency committee
insurance, health, reimbursement
adult
hemostasis, surgical
Biological glue (substance)
drug therapy, combination
thrombin
fibrinogen
improvement of surgical hemostasis
suture reinforcement in vascular surgery
suture techniques
blood vessels
hemostatics
local hemostatics
Epilesional Route of Administration

---
https://www.has-sante.fr/jcms/p_3263675/fr/fibryga-fibrinogene-humain
2021
false
false
false
France
treatment outcome
insurance, health, reimbursement
human fibrinogen
blood loss, surgical
blood loss, surgical
congenital afibrinogenemia
Congenital hypofibrinogenemia (disorder)
Acquired hypofibrinogenemia (disorder)
injections, intravenous
infusions, intravenous
evaluation of the transparency committee
fibrinogen
afibrinogenemia

---
https://www.has-sante.fr/jcms/p_3243406/fr/veraseal
2021
false
false
false
France
treatment outcome
insurance, health, reimbursement
drug combinations
Product containing only human fibrinogen and thrombin (medicinal product)
fibrinogen
thrombin
adult
hemostatics
local hemostatics
administration, topical
vascular surgical procedures
evaluation of the transparency committee

---
https://www.has-sante.fr/jcms/p_3221742/fr/clottafact
2020
false
false
false
France
fibrinogen
insurance, health, reimbursement
treatment outcome
human fibrinogen
adult
adolescent
child
Dysfibrinogenemia
Afibrinogenemia
Hypofibrinogenemia
afibrinogenemia
surgical procedures, operative
hemorrhage
injections, intravenous
evaluation of the transparency committee

---
https://www.ansm.sante.fr/actualites/fibrinogene-humain-lansm-a-elabore-un-guide-pratique-pour-favoriser-le-bon-usage-des-produits-disponibles
2019
false
false
false
France
French
fibrinogen
guidelines for drug use
fibrinogen
afibrinogenemia
hemorrhage
drug storage
drug compounding
Acquired hypofibrinogenemia (disorder)
human fibrinogen

---
https://www.ansm.sante.fr/actualites/fibrinogene-humain-lansm-a-elabore-un-guide-pratique-pour-favoriser-le-bon-usage-des-produits-disponibles
2019
false
false
false
France
drug storage
drug compounding
guidelines for drug use
france
fibrinogen

---
http://www.has-sante.fr/portail/jcms/c_2676747/fr/tachosil
2016
false
false
false
France
French
evaluation of the transparency committee
drug combinations
fibrinogen
thrombin
adult
postoperative complications
neurosurgical procedures
dura mater
tissue adhesives
combinations
Cerebrospinal Fluid Leak
Postoperative cerebrospinal fluid leak (disorder)

---
http://www.has-sante.fr/portail/jcms/c_2049889/fr/tisseel
http://www.has-sante.fr/portail/jcms/c_2049889/fr/tisseel-solution-congelee-pour-colle-a-base-de-fibrinogene-et-de-thrombine-humains
2015
false
false
false
France
French
evaluation of the transparency committee
guidelines for drug use
drug therapy, combination
drug combinations
fibrin tissue adhesive
tissue adhesives
hemostatics
treatment outcome
combinations
fibrinogen
aprotinin
calcium chloride
thrombin
hemostasis
surgical procedures, operative

---
http://www.has-sante.fr/portail/jcms/c_2049883/fr/evarrest
http://www.has-sante.fr/portail/jcms/c_2049883/fr/evarrest-matrice-pour-colle-a-base-de-fibrinogene-et-de-thrombine-humains
2015
false
France
French
evaluation of the transparency committee
insurance, health, reimbursement
hemostasis, surgical
guidelines for drug use
combinations
fibrinogen
thrombin
drug combinations
fibrinogen
thrombin
treatment outcome
adult
blood loss, surgical
administration, topical
hemostatics
hemostatics
coagulants
coagulants

---
Mise à disposition d’une présentation sous forme de matrice pré-enroulée en complément des présentations existantes
http://www.has-sante.fr/portail/jcms/c_2031548/fr/tachosil
2015
false
true
false
France
French
evaluation of the transparency committee
drug combinations
fibrinogen
thrombin
adult
postoperative complications
tissue adhesives
combinations
TachoSil
hemostasis, surgical
vascular surgical procedures
surgical procedures, operative
suture techniques
hemostatics
fibrinogen
thrombin

---
https://www.ema.europa.eu/medicines/human/EPAR/Raplixa
2015
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
combinations
drug combinations
fibrinogen
fibrinogen
drug approval
europe
thrombin
thrombin
adult
gelatin sponge, absorbable
powders
product surveillance, postmarketing
hemostatics
hemostatics
aged
hemostasis, surgical

---
http://www.has-sante.fr/portail/jcms/c_1774119/fr/evicel
2014
false
France
French
evaluation of the transparency committee
neurosurgical procedures
reinforcement, nos
suture of cerebral dura mater
surgical wound dehiscence
drug combinations
fibrin tissue adhesive
fibrinogen
fibronectins
thrombin
tissue adhesives
administration, topical
treatment outcome
tissue adhesives
fibrin tissue adhesive
fibrinogen
fibronectins
thrombin

---
https://www.ema.europa.eu/medicines/human/EPAR/Evarrest
2013
false
United Kingdom
French
English
hemostasis, surgical
combinations
fibrinogen
thrombin
drug combinations
fibrinogen
thrombin
drug approval
treatment outcome
europe
summary of product characteristics
package leaflet
drug evaluation
syndication feed
adult
blood loss, surgical
administration, topical
hemostatics
hemostatics
coagulants
coagulants
product surveillance, postmarketing
drug evaluation, preclinical

---
http://www.cochrane.org/fr/CD008864
2013
United Kingdom
France
French
french abstract
treatment outcome
fibrinogen
afibrinogenemia
hemorrhage
meta-analysis

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61179660
2012
France
summary of product characteristics
package leaflet
fibrinogen
humans
powders

---
https://www.ema.europa.eu/medicines/human/EPAR/Evicel
2012
United Kingdom
English
French
syndication feed
hemostasis, surgical
treatment outcome
drug labeling
administration, topical
pharmaceutical solutions
drug evaluation, preclinical
thrombin
drug combinations
thrombin
fibrinogen
fibrinogen
tissue adhesives
tissue adhesives
fibrin tissue adhesive
fibrin tissue adhesive
hemostatics
drug approval
local hemostatics
summary of product characteristics
package leaflet
drug evaluation

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=93580
2011
France
scientific and technical information
fibrinogen
Atypical hemolytic uremic syndrome
hemolytic-uremic syndrome

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=93562
2011
France
scientific and technical information
amyloid
amyloidosis, familial visceral
amyloidosis
fibrinogen
amyloidosis
amylose
amyloidosis, nos

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=200418
2011
France
scientific and technical information
complement factor I deficiency
immunocompromised host
immunologic deficiency syndromes
fibrinogen
complement factor I deficiency

---
https://www.ema.europa.eu/medicines/human/EPAR/TachoSil
2011
United Kingdom
French
English
syndication feed
TachoSil
drug combinations
blood loss, surgical
fibrinogen
surgical sponges
thrombin
treatment outcome
drug evaluation
hemostasis, surgical
hemostatics
postoperative hemorrhage
adult
fibrinogen
thrombin
breast feeding
pregnancy
thrombin
thrombin
fibrinogen
fibrinogen
drug labeling
drug approval
combinations
drug evaluation
summary of product characteristics
package leaflet

---
http://www.has-sante.fr/portail/jcms/c_1036540/riastap
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-04/riastap_-_ct-_9732.pdf
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-11/riastap_ct_9732.pdf
2011
France
French
English
human fibrinogen
fibrinogen
hemostatics
hemorrhage
afibrinogenemia
injections, intravenous
infusions, intravenous
treatment outcome
fibrinogen
hemostatics
evaluation of the transparency committee
guidelines for drug use

---
http://www.has-sante.fr/portail/jcms/c_1058947/riastap-fibrinogene-humain
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-04/riastap_-_ct-_9732.pdf
2011
France
French
evaluation of the transparency committee
guidelines for drug use
treatment outcome
fibrinogen
injections, intravenous
infusions, intravenous
fibrinogen
human fibrinogen
hemorrhage
afibrinogenemia
afibrinogenemia

---
http://www.has-sante.fr/portail/jcms/c_887287/evicel
http://www.has-sante.fr/portail/upload/docs/application/pdf/2009-12/evicel_-_ct-_6940.pdf
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-06/evicel_ct_6940.pdf
2009
France
French
English
evaluation of the transparency committee
local hemostatics
drug combinations
fibrin tissue adhesive
fibrinogen
fibronectins
thrombin
hemostatics
tissue adhesives
administration, topical
treatment outcome
hemostatics
tissue adhesives
fibrin tissue adhesive
fibrinogen
fibronectins
thrombin

---
http://www.has-sante.fr/portail/jcms/c_849254/clottafact-fibrinogene-humain
http://www.has-sante.fr/portail/jcms/c_827813/clottafact-ct6697
http://www.has-sante.fr/portail/jcms/c_849253/synthese-d-avis-clottafact-ct-6697
2009
France
French
afibrinogenemia
adult
child
injections, intravenous
treatment outcome
fibrinogen
fibrinogen
human fibrinogen
guidelines for drug use
evaluation of the transparency committee

---
https://www.amub-ulb.be/system/files/rmb/old/40
2003
Belgium
French
fibrinogen
journal article

---
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