aprotinin - CISMeF

Preferred Label : aprotinin;

MeSH definition : A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995);

MeSH synonym : kunitz pancreatic trypsin inhibitor; basic pancreatic trypsin inhibitor; trypsin inhibitor, kunitz, pancreatic; kallikrein-trypsin inactivator; trypsin inhibitor, basic, pancreatic; bovine kunitz pancreatic trypsin inhibitor; bovine pancreatic trypsin inhibitor; inactivator, kallikrein-trypsin; kallikrein trypsin inactivator; bpti, basic pancreatic trypsin inhibitor;

CISMeF synonym : trypsin inhibitor, pancreatic basic; arzneimittelwerk dresden brand of aprotinin; bayer brand of aprotinin; sanofi winthrop brand of aprotinin;

MeSH hyponym : antilysin; contrykal; iniprol; zymofren; pulmin; traskolan; dilmintal; Kontrykal; Kontrikal; Contrical;

Related MeSH term : trasylol;

MeSH Related Number : 9004-04-0 (other number);

Registry Number MeSH : 9087-70-1;

Wikipedia link : https://en.wikipedia.org/wiki/Aprotinin;

Codes EINECS : 232-994-9;

Is substance : O;

Details

Origin ID

D007611;

UMLS CUI

C0003641;

ATC code(s)
- aprotinin [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- trypsin inhibitor, pancreatic basic [Substance BNPC]
Currated CISMeF NLP mapping
- Aprotinin [ICD-11 Extension code]
- Aprotinin [ICHI extension code]
- Aprotinin [SMS substance]
- Aprotinin [NCIt concept]
- Aprotinin (substance) [SNOMED CT concept]
Pharmacological action(s)
- hemostatics [MeSH Descriptor]
- trypsin inhibitors [MeSH Descriptor]
Record concept(s)
- antilysin [MeSH concept]
- aprotinin [MeSH concept]
- contrykal [MeSH concept]
- dilmintal [MeSH concept]
- iniprol [MeSH concept]
- pulmin [MeSH concept]
- traskolan [MeSH concept]
- trasylol [MeSH concept]
- zymofren [MeSH concept]
Related MeSH Supplementary Concept(s)
- (homoserine lactone-52)-52,53-seco-BPTI [MeSH Supplementary Concept]
- FTCH hemostatic [MeSH Supplementary Concept]
- antagosan [MeSH Supplementary Concept]
- aprotinin, Arg(15)-Glu(52)- [MeSH Supplementary Concept]
- aprotinin, desprolyl(2)-arginyl(15)- [MeSH Supplementary Concept]
- aprotinin, desprolyl(2)-valyl(15)-leucyl(17)- [MeSH Supplementary Concept]
- beriplast P combi set [MeSH Supplementary Concept]
- circular bovine pancreatic trypsin inhibitor [MeSH Supplementary Concept]
- eupergit-aprotinin [MeSH Supplementary Concept]
- gordox [MeSH Supplementary Concept]
- preproaprotinin [MeSH Supplementary Concept]
- recombinant kunitz protease inhibitor [MeSH Supplementary Concept]
- recombinant neutrophil elastase inhibitor R-020 [MeSH Supplementary Concept]
- spleen protease inhibitor II [MeSH Supplementary Concept]
- tachocomb [MeSH Supplementary Concept]
- technetium tc 99m aprotinin [MeSH Supplementary Concept]
- trasylol, Arg(15)- [MeSH Supplementary Concept]
- tsalol [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Aprotinin [ICD-11 Extension code]
- Aprotinin [NCIt concept]
- Aprotinin (substance) [SNOMED CT concept]
- Product containing aprotinin (medicinal product) [SNOMED CT concept]
- aprotinin [ATC Code]
- trypsin inhibitor, pancreatic basic [Substance BNPC]
Validated automatic mappings to BTNT
- Bovine aprotinin [SMS substance]
- aprotinin [ATC Code]

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