dextromethorphan

Preferred Label : dextromethorphan;

MeSH definition : Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.;

MeSH synonym : d-methorphan;

CISMeF synonym : 125-69-9 (Dextromethorphan hydrobromide); 18609-21-7 (Dextromethorphan hydrochloride);

MeSH Hyperonym : racemethorphan;

MeSH hyponym : Dextromethorphan Hydrobromide; dextromethorphan hydrochloride; delsym; Dextromethorphan Hydrobromide, Monohydrate; Hydrobromide, Dextromethorphan; Hydrochloride, Dextromethorphan;

Related MeSH term : l-Methorphan; dextromethorphan hydrobromide, ( -)-Isomer; dextromethorphan hydrobromide, ( -)-Isomer; Dextromethorphan, ( -)-Isomer; Dextromethorphan, ( -)-Isomer; levomethorphan;

MeSH CAS label : morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-;

MeSH Related Number : dextromethorphan, ( -)-Isomer; dextromethorphan, ( -)-Isomer; dextromethorphan hydrobromide, monohydrate; dextromethorphan hydrobromide; dextromethorphan hydrobromide, ( -)-Isomer; dextromethorphan hydrobromide, ( -)-Isomer; dextromethorphan hydrochloride; 125-68-8 (HBr, cpd w/o isomeric designation); 125-69-9 (HBr); 125-71-3 (Dextromethorphan); 18609-21-7 (HCl); 510-53-2 (( -)-isomer); 510-53-2 (( -)-isomer); 6031-86-3 (HBr, ( -)-isomer); 6031-86-3 (HBr, ( -)-isomer); 6700-34-1 (HBr, mono-hydrate); levomethorphan; racemethorphan; 351KFH969D; 7ZZ22K9QE6; 8YB8F78WM1; 9D2RTI9KYH;

Libelles Related CAS CISMeF : racéméthorphane;

Registry Number MeSH : 125-71-3;

Related CAS MeSH : 510-53-2 (Dextromethorphan, ( -)-Isomer); 510-53-2 (Dextromethorphan, ( -)-Isomer); 6700-34-1 (Dextromethorphan hydrobromide, monohydrate); 6031-86-3 (Dextromethorphan hydrobromide, ( -)-Isomer); 6031-86-3 (Dextromethorphan hydrobromide, ( -)-Isomer); 7ZZ22K9QE6 (Levomethorphan); 9D2RTI9KYH (Dextromethorphan hydrobromide); 351KFH969D (Dextromethorphan hydrochloride); 8YB8F78WM1 (Racemethorphan);

Wikipedia link : https://en.wikipedia.org/wiki/Dextromethorphan;

Codes EINECS : 204-752-2;

Is substance : O;

UNII : 7355X3ROTS;

InChIKey : MKXZASYAUGDDCJ-NJAFHUGGSA-N;

Details

Origin ID

D003915;

UMLS CUI

C0011816;

ATC code(s)
- dextromethorphan [ATC Code]
ATC code(s)
- bupropion and dextromethorphan [ATC Code]
- dextromethorphan [ATC Code]
- dextromethorphan, combinations [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Racemethorphan [NCIt concept]
- racemethorphan [Substance BNPC]
CISMeF manual mappings
- Dextromethorphan measurement (procedure) [SNOMED CT concept]
- Poisoning caused by dextromethorphan (disorder) [SNOMED CT concept]
- dextromethorphan [Substance BNPC]
Currated CISMeF NLP mapping
- Dextromethorphan [ICD-11 Extension code]
- Dextromethorphan [LOINC component]
- Dextromethorphan [ICHI extension code]
- Dextromethorphan [NCIt concept]
- Dextromethorphan (substance) [SNOMED CT concept]
- dextromethorphan [International Nonproprietary Name]
- dextromethorphan [SNOMED Notion]
Exact mapping(s) to DCI
- dextromethorphan [International Nonproprietary Name]
Pharmacological action(s)
- antitussive agents [MeSH Descriptor]
- excitatory amino acid antagonists [MeSH Descriptor]
- neurotransmitter agents [MeSH Descriptor]
Record concept(s)
- Dextromethorphan Hydrobromide [MeSH concept]
- Dextromethorphan Hydrobromide, Monohydrate [MeSH concept]
- Dextromethorphan, (+-)-Isomer [MeSH concept]
- delsym [MeSH concept]
- dextromethorphan [MeSH concept]
- dextromethorphan hydrobromide, (+-)-Isomer [MeSH concept]
- dextromethorphan hydrochloride [MeSH concept]
- racemethorphan [MeSH concept]
Related MeSH Supplementary Concept(s)
- 3-methoxymorphinan [MeSH Supplementary Concept]
- AHN 649 [MeSH Supplementary Concept]
- EN 3231 [MeSH Supplementary Concept]
- acetaminophen, chlorpheniramine, dextromethorphan, phenylpropanolamine drug combination [MeSH Supplementary Concept]
- acetaminophen, dextromethorphan, doxylamine succinate, pseudoephedrine drug combination [MeSH Supplementary Concept]
- acetaminophen, pholcodine, pseudoephedrine drug combination [MeSH Supplementary Concept]
- carbinoxamine, dextromethorphan, pseudoephedrine drug combination [MeSH Supplementary Concept]
- chlorphenamine, dextromethorphan, phenylephrine drug combination [MeSH Supplementary Concept]
- d-3-methoxy-N-hydroxyethyl morphinan [MeSH Supplementary Concept]
- dextromethorphan - quinidine combination [MeSH Supplementary Concept]
- night nurse [MeSH Supplementary Concept]
- norlevorphanol [MeSH Supplementary Concept]
- nyquil [MeSH Supplementary Concept]
- sch 399 [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Levomethorphan [NCIt concept]
- Product containing dextromethorphan (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dextromethorphan [LOINC component]
- Dextromethorphan [ICD-11 Extension code]
- Dextromethorphan [NCIt concept]
- Dextromethorphan (substance) [SNOMED CT concept]
- Product containing dextromethorphan (medicinal product) [SNOMED CT concept]
- dextromethorphan [ATC Code]
- dextromethorphan [Substance BNPC]
- dextromethorphan [International Nonproprietary Name]
- dextromethorphan [SNOMED Notion]
Validated automatic mappings to BTNT
- Dextromethorphan Hydrobromide [NCIt concept]
- Dextromethorphan hydrobromide (substance) [SNOMED CT concept]
- Dextromethorphan hydrobromide monohydrate (substance) [SNOMED CT concept]
- dextromethorphan [ATC Code]
- dextromethorphan hydrobromide [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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