Tucatinib - CISMeF

Preferred Label : Tucatinib;

NCIt synonyms : N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine; ErbB-2 Inhibitor ARRY-380; Irbinitinib;

NCIt definition : An orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. Tucatinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.;

UNII : 234248D0HH;

InChIKey : SDEAXTCZPQIFQM-UHFFFAOYSA-N;

CAS number : 937263-43-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 937263-43-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Tukysa;

Molecule name : ARRY-380; ONT-380;

NCI Metathesaurus CUI : CL383576;

Codes from synonyms : 4683;

Details

Origin ID

C77896;

UMLS CUI

C4519167;

Automatic exact mappings (from CISMeF team)
- N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine [MeSH concept]
Currated CISMeF NLP mapping
- Tucatinib (substance) [SNOMED CT concept]
- tucatinib [MeSH Supplementary Concept]
- tucatinib [MeSH concept]
Manual BTNT mappings - CISMeF
- tucatinib [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tucatinib (medicinal product) [SNOMED CT concept]
- Tucatinib (substance) [SNOMED CT concept]
- tucatinib [MeSH Supplementary Concept]
- tucatinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Capecitabine/Trastuzumab/Tucatinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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recommendations
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