Preferred Label : Gimatecan;
NCIt synonyms : 7-t-Butoxyiminomethylcamptothecin;
NCIt related terms : ST1481;
NCIt definition : An orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline
alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic
and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase
I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation
of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded
DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication
machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although
the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent
may inhibit endothelial cell migration, tumor neovascularization, and the expression
of proangiogenic basic fibroblast growth factor (bFGF).;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called topoisomerase inhibitors.;
UNII : 7KKS9R192F;
InChIKey : UIVFUQKYVFCEKJ-OPTOVBNMSA-N;
CAS number : 292618-32-7;
Molecule name : STI481; LBQ707;
Chemical formula : C25H25N3O5;
Codes from synonyms : CDR0000386216; CDR0000386214;
Origin ID : C65804;
UMLS CUI : C1455513;
Automatic exact mappings (from CISMeF team)
- ST 1481 [MeSH Supplementary Concept]
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
