Ivermectin - CISMeF

Preferred Label : Ivermectin;

NCIt synonyms : Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-;

NCIt definition : An orally bioavailable macrocyclic lactone derived from Streptomyces avermitilis, with antiparasitic and potential anti-viral activities. Upon administration, ivermectin exerts its anthelmintic effect through binding and activating glutamate-gated chloride channels (GluCls) expressed on nematode neurons and pharyngeal muscle cells. This causes increased permeability of chloride ions, causing a state of hyperpolarization and results in the paralysis and death of the parasite. Ivermectin may exerts its antiviral effect, including its potential activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), by binding to the importin (IMP) alpha/beta1 heterodimer, which is responsible for the nuclear import of viral proteins such as the integrase (IN) protein. This inhibits nuclear import of host and viral proteins and may inhibit viral replication.;

UNII : 8883YP2R6D;

CAS number : 70288-86-7;

Drug name : Stromectol; Sklice;

ChEBI ID : CHEBI:6078;

Details

Origin ID

C61796;

UMLS CUI

C0022322;

Automatic exact mappings (from CISMeF team)
- Skin [LOINC System]
- Skin [LOINC component]
- avermectin a1a, 5-o-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- [Substance BNPC]
- skin [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ivermectin [ICD-11 Extension code]
- Ivermectin (substance) [SNOMED CT concept]
- Product containing ivermectin (medicinal product) [SNOMED CT concept]
- ivermectin [ATC Code]
- ivermectin [ATC Code]
- ivermectin [Substance BNPC]
- ivermectin [MeSH concept]
- ivermectin [MeSH Descriptor]
- ivermectin [SNOMED Notion]
Validated automatic mappings to BTNT
- ivermectin [ATC Code]
- ivermectin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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