Tiludronate Disodium

Preferred Label : Tiludronate Disodium;

NCIt definition : The disodium salt form of tiludronate, a first-generation, non-nitrogenous bisphosphonate analogue of endogenous pyrophosphate. Tiludronate adsorbs to hydroxyapatite cells, and although the exact mechanism through which this bisphosphonate exerts its effect has yet to be fully elucidated, tiludronate appears to inhibit protein-tyrosine-phosphatase (PTP) in osteoclasts, thereby disrupting the cytoskeletal ring structure and suppressing the bone resorbing activity of osteoclasts. In addition, tiludronate appears to inhibit the vacuolar-type proton ATPase (V-ATPase) in osteoclasts. Altogether, this may reduce the number of osteoclasts, inhibit abnormal bone resorption and reduce bone turnover.;

UNII : BH6M93CIA0;

InChIKey : SKUHWSDHMJMHIW-UHFFFAOYSA-L;

CAS number : 149845-07-8;

Drug name : Skelid;

Chemical formula : C7H7ClO6P2S.2Na;

Details

Origin ID

C61973;

UMLS CUI

C0286030;

Automatic exact mappings (from CISMeF team)
- Skin [LOINC System]
- Skin [LOINC component]
- skin [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Tiludronate disodium (substance) [SNOMED CT concept]
- tiludronate disodium [MeSH concept]
- tiludronic acid disodium salt [International Nonproprietary Name]
Validated automatic mappings to NTBT
- tiludronic acid [MeSH Supplementary Concept]
- tiludronic acid disodium salt [International Nonproprietary Name]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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