Lung Small Cell Carcinoma

Preferred Label : Lung Small Cell Carcinoma;

NCIt synonyms : Small Cell Carcinoma of Lung; Small Cell Neuroendocrine Carcinoma of Lung; SCLC; Small Cell Lung Cancer; Lung Small Cell Neuroendocrine Carcinoma; Small Cell Carcinoma of the Lung; Small Cell Neuroendocrine Carcinoma of the Lung; Oat Cell Carcinoma of the Lung; Lung Oat Cell Carcinoma; Oat Cell Carcinoma of Lung; Oat Cell Lung Carcinoma; Small Cell Lung Carcinoma;

NCIt definition : A highly aggressive carcinoma with neuroendocrine differentiation arising from the lung. It is characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis.;

Alternative definition : NCI-GLOSS: An aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.;

Neoplastic status : Malignant;

Codes from synonyms : 10041071; CDR0000045327;

Details

Origin ID

C4917;

UMLS CUI

C0149925;

Automatic exact mappings (from CISMeF team)
- Small cell lung cancer [ICD-11 More detail]
- carcinoma, small cell [MeSH Descriptor]
- lung cancer [MedlinePlus Topic]
- lung oat cell carcinoma [DO Concept]
Currated CISMeF NLP mapping
- Oat cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell cancer of the lung [OMIM Phenotype]
- Small cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell carcinoma of the lung [MedDRA LLT]
- Small cell lung cancer [MedDRA Preferred Term]
- Small cell lung cancer [ORDO Disease]
- Small cell lung cancer stage unspecified [MedDRA LLT]
- Small cell lung carcinoma [HPO term]
- lung small cell carcinoma [DO Concept]
- small cell lung carcinoma [Disease (Nov.)]
- small cell lung carcinoma [MeSH Descriptor]
- small cell lung carcinoma [MeSH concept]
DO Cross reference
- lung small cell carcinoma [DO Concept]
Disease excludes abnormal cell
- Large Osteoclastic Giant Cell [NCIt concept]
- Malignant Neuroendocrine Large Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Neuron-Specific Enolase Positive Neoplastic Cells Present [NCIt concept]
- Rosette Formation [NCIt concept]
- Sheet-Like Growth Pattern [NCIt concept]
- Trabecular Pattern [NCIt concept]
Excludes anatomical site(s)
- Head and Neck [NCIt concept]
- Neck [NCIt concept]
Has associated anatomic sites
- Lung [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Oat cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell cancer of the lung [OMIM Phenotype]
- Small cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell carcinoma of the lung [MedDRA LLT]
- Small cell lung cancer [MedDRA Preferred Term]
- Small cell lung cancer [ORDO Disease]
- Small cell lung cancer progression [MedDRA LLT]
- Small cell lung cancer stage unspecified [MedDRA LLT]
- Small cell lung carcinoma [HPO term]
- lung small cell carcinoma [DO Concept]
- small cell lung carcinoma [Disease (Nov.)]
- small cell lung carcinoma [MeSH concept]
- small cell lung carcinoma [MeSH Descriptor]
associated_with_malfunction_of_gene_product
- Protein L-Myc [NCIt concept]
- RNA-Binding Protein Nova-1 [NCIt concept]
- Reticulon-1 [NCIt concept]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Portfolio Management Subtype Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- NCI CTEP SDC Small Cell Lung Cancer Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Intermediate Grade Neuroendocrine Lesion [NCIt concept]
- Premalignant Lesion [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Endocrine Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Neuroendocrine Cell [NCIt concept]
- Malignant Neuroendocrine Small Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Neuroendocrine Cell [NCIt concept]
disease_has_accepted_treatment_with_regimen
- CAE Regimen [NCIt concept]
- CAV Regimen [NCIt concept]
- Carboplatin/Etoposide Regimen [NCIt concept]
- Carboplatin/Topotecan Regimen [NCIt concept]
- Cisplatin/Irinotecan Regimen [NCIt concept]
- Cyclophosphamide/Etoposide/Vincristine Regimen [NCIt concept]
- EP Regimen [NCIt concept]
- EVAC Regimen [NCIt concept]
- PET Regimen [NCIt concept]
- TEC Regimen [NCIt concept]
disease_has_associated_gene
- MYCL Gene [NCIt concept]
- MYCL wt Allele [NCIt concept]
- NOVA1 Gene [NCIt concept]
- NOVA1 wt Allele [NCIt concept]
- Oncogene MYCN [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- High Grade Lesion [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- More than 10 Mitoses per 10HPF [NCIt concept]
- Necrotic Change [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Nuclear Molding [NCIt concept]
- Peripheral Nuclear Palisading [NCIt concept]
- Poorly Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bronchus [NCIt concept]
- Lung [NCIt concept]
disease_mapped_to_gene
- TP53 Gene [NCIt concept]
disease_may_have_associated_disease
- Paraneoplastic Syndrome [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 17q [NCIt concept]
- Gain of Chromosome 19 [NCIt concept]
- Gain of Chromosome 20q [NCIt concept]
- Gain of Chromosome 3q [NCIt concept]
- Gain of Chromosome 5p [NCIt concept]
- Gain of Chromosome 6p [NCIt concept]
- Gain of Chromosome 8q [NCIt concept]
- Loss of Chromosome 10q [NCIt concept]
- Loss of Chromosome 17p [NCIt concept]
- Loss of Chromosome 18q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
- Loss of Chromosome 4 [NCIt concept]
- Loss of Chromosome 5q [NCIt concept]
- del(13q14) [NCIt concept]
disease_may_have_molecular_abnormality
- C-KIT Tyrosine Kinase Protein Overexpression [NCIt concept]
- FGFR1 Gene Amplification [NCIt concept]
- NMYC Gene Amplification [NCIt concept]
- PTEN Gene Mutation [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]
has_biomarker_gene_product
- Gamma-Enolase [NCIt concept]
neoplasm_has_special_category
- Solid Neoplasm [NCIt concept]

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