Lung Small Cell Carcinoma

Preferred Label : Lung Small Cell Carcinoma;

NCIt synonyms : Small Cell Carcinoma of Lung; Small Cell Neuroendocrine Carcinoma of Lung; SCLC; Small Cell Lung Cancer; Lung Small Cell Neuroendocrine Carcinoma; Small Cell Carcinoma of the Lung; Small Cell Neuroendocrine Carcinoma of the Lung; Oat Cell Carcinoma of the Lung; Lung Oat Cell Carcinoma; Oat Cell Carcinoma of Lung; Oat Cell Lung Carcinoma; Small Cell Lung Carcinoma;

NCIt definition : A highly aggressive carcinoma with neuroendocrine differentiation that arises from the lung. It is characterized by the presence of malignant small cells and more than 10 mitoses per 2 mm2. Necrosis is frequently seen. Metastatic disease is usually present at the time of diagnosis.;

Alternative definition : NCI-GLOSS: An aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.;

Neoplastic status : Malignant;

Codes from synonyms : 10041071; CDR0000045327;

Details

Origin ID

C4917;

UMLS CUI

C0149925;

Automatic exact mappings (from CISMeF team)
- Small cell lung cancer [ICD-11 More detail]
- carcinoma, small cell [MeSH Descriptor]
- lung cancer [MedlinePlus Topic]
- lung oat cell carcinoma [DO Concept]
Currated CISMeF NLP mapping
- Oat cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell cancer of the lung [OMIM Phenotype]
- Small cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell carcinoma of the lung [MedDRA LLT]
- Small cell lung cancer [MedDRA Preferred Term]
- Small cell lung cancer [ORDO Disease]
- Small cell lung cancer stage unspecified [MedDRA LLT]
- Small cell lung carcinoma [HPO term]
- lung small cell carcinoma [DO Concept]
- small cell lung carcinoma [Disease (Nov.)]
- small cell lung carcinoma [MeSH Descriptor]
- small cell lung carcinoma [MeSH concept]
DO Cross reference
- lung small cell carcinoma [DO Concept]
Disease excludes abnormal cell
- Large Osteoclastic Giant Cell [NCIt concept]
- Malignant Neuroendocrine Large Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Endothelial Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease excludes normal cell origin
- Endothelial Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Neuron-Specific Enolase Positive Neoplastic Cells Present [NCIt concept]
- Rosette Formation [NCIt concept]
- Sheet-Like Growth Pattern [NCIt concept]
- Trabecular Pattern [NCIt concept]
Excludes anatomical site(s)
- Head and Neck [NCIt concept]
- Neck [NCIt concept]
Has associated anatomic sites
- Lung [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Oat cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell cancer of the lung [OMIM Phenotype]
- Small cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell carcinoma of the lung [MedDRA LLT]
- Small cell lung cancer [MedDRA Preferred Term]
- Small cell lung cancer [ORDO Disease]
- Small cell lung cancer progression [MedDRA LLT]
- Small cell lung cancer stage unspecified [MedDRA LLT]
- Small cell lung carcinoma [HPO term]
- lung small cell carcinoma [DO Concept]
- small cell lung carcinoma [Disease (Nov.)]
- small cell lung carcinoma [MeSH concept]
- small cell lung carcinoma [MeSH Descriptor]
associated_with_malfunction_of_gene_product
- Protein L-Myc [NCIt concept]
- RNA-Binding Protein Nova-1 [NCIt concept]
- Reticulon-1 [NCIt concept]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Portfolio Management Subtype Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- NCI CTEP SDC Small Cell Lung Cancer Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Intermediate Grade Neuroendocrine Lesion [NCIt concept]
- Premalignant Lesion [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Endocrine Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Neuroendocrine Cell [NCIt concept]
- Malignant Neuroendocrine Small Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Neuroendocrine Cell [NCIt concept]
disease_has_accepted_treatment_with_regimen
- Carboplatin/Etoposide Regimen [NCIt concept]
- Carboplatin/Topotecan Regimen [NCIt concept]
- Cisplatin/Irinotecan Regimen [NCIt concept]
- Cyclophosphamide/Doxorubicin/Vincristine Regimen [NCIt concept]
- Cyclophosphamide/Etoposide/Vincristine Regimen [NCIt concept]
- EP Regimen [NCIt concept]
- EVAC Regimen [NCIt concept]
- PET Regimen [NCIt concept]
- TEC Regimen [NCIt concept]
disease_has_associated_gene
- MYCL Gene [NCIt concept]
- MYCL wt Allele [NCIt concept]
- NOVA1 Gene [NCIt concept]
- NOVA1 wt Allele [NCIt concept]
- Oncogene MYCN [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Expression of Neuroendocrine Markers Present [NCIt concept]
- High Grade Lesion [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- More than 10 Mitoses per 10HPF [NCIt concept]
- Necrotic Change [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Nuclear Molding [NCIt concept]
- Peripheral Nuclear Palisading [NCIt concept]
- Poorly Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bronchus [NCIt concept]
- Lung [NCIt concept]
disease_mapped_to_gene
- TP53 Gene [NCIt concept]
disease_may_have_associated_disease
- Paraneoplastic Syndrome [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 17q [NCIt concept]
- Gain of Chromosome 19 [NCIt concept]
- Gain of Chromosome 20q [NCIt concept]
- Gain of Chromosome 3q [NCIt concept]
- Gain of Chromosome 5p [NCIt concept]
- Gain of Chromosome 6p [NCIt concept]
- Gain of Chromosome 8q [NCIt concept]
- Loss of Chromosome 10q [NCIt concept]
- Loss of Chromosome 17p [NCIt concept]
- Loss of Chromosome 18q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
- Loss of Chromosome 4 [NCIt concept]
- Loss of Chromosome 5q [NCIt concept]
- del(13q14) [NCIt concept]
disease_may_have_molecular_abnormality
- C-KIT Tyrosine Kinase Protein Overexpression [NCIt concept]
- FGFR1 Gene Amplification [NCIt concept]
- NMYC Gene Amplification [NCIt concept]
- PTEN Gene Mutation [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]
has_biomarker_gene_product
- Gamma-Enolase [NCIt concept]
neoplasm_has_special_category
- Solid Neoplasm [NCIt concept]

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