Reticulon-1 - CISMeF

Preferred Label : Reticulon-1;

NCIt synonyms : Reticulon 1; Neuroendocrine-Specific Protein; NSP; RTN1;

NCIt definition : Reticulon-1 (776 aa, 84 kDa) is encoded by the human RTN1 gene. This protein may play a role in neuroendocrine secretion or membrane trafficking.;

NCIt note : Reticulon-1 is expressed as three isoforms (A, B, C) with unique N termini. According to UniProt, RTN1-A (NSP-A) is the canonical form; RTN1-B (NSP-B) is 356-aa and RTN1-C (NSP-C) is 208-aa. RTN1-A and RTN1-B are phosphorylated and expression of RTN1-C is correlated with neuronal differentiation. (UniProt);

Details

Origin ID

C17692;

UMLS CUI

C0217373;

OMIM relation
- Reticulon 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RTN1 protein, human [MeSH Supplementary Concept]
- RTN1 protein, human [MeSH concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- RTN1 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Neuroendocrine Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_chemical_classification
- Phosphoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_malfunction_associated_with_disease
- Lung Small Cell Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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