Oncogene MYCN - CISMeF

Preferred Label : Oncogene MYCN;

NCIt synonyms : Oncogene NMYC; v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian); N-MYC; Neuroblastoma MYC Oncogene;

NCIt definition : Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are phosphorylated, exceptionally unstable and bind to single- and double-stranded DNA. N-MYC is a likely heterodimeric bZIP transcription factor with MAX; efficient DNA binding requires dimerization with another bHLH protein. NMYC amplification is associated with oncogenic transformation. Oncogene NMYC disrupts normal cell function.;

NCI Metathesaurus CUI : CL1642990;

GenBank Accession Number : NM_005378;

Details

Origin ID

C18444;

UMLS CUI

C0812287;

OMIM relation
- Mycn protooncogene, bhlh transcription factor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- MYCN gene [LOINC component]
- MYCN proto-oncogene, bHLH transcription factor [HGNC gene]
- Mycn protooncogene, bhlh transcription factor [OMIM gene]
allele_in_chromosomal_location
- 2p24.1 [NCIt concept]
gene_associated_with_disease
- Lung Small Cell Carcinoma [NCIt concept]
- Neuroblastoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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