" /> NOVA1 wt Allele - CISMeF





Preferred Label : NOVA1 wt Allele;

NCIt synonyms : Ri Antigen Gene; Neuro-Oncological Ventral Antigen 1 wt Allele; Nova-1;

NCIt definition : Human NOVA1 wild-type allele is located within 14q and is approximately 152 kb in length. This allele, which encodes RNA-binding protein Nova-1, is involved in the regulation of RNA splicing or metabolism in a specific population of developing neurons.;

NCIt note : Human NOVA1 Gene (NOVA Family) at 14q encodes NOVA-1, a neuron-specific nuclear RNA-binding protein containing three KH domains. Alternative transcript variants differ by a seventy-two base pair exon H, as well as by a nine base pair motif. NOVA-1 may regulate RNA splicing or metabolism in specific developing neurons. Murine Nova1 is expressed in ventral spinal cord, brain stem nuclei, deep cerebellar nuclei, and hypothalamus. It binds RNA in a sequence-specific manner to regulate neuron-specific splicing of inhibitory receptor pre-mRNAs in postnatal motor neurons. Nova1 also specifically binds to the GLRA2 intronic sequence (UCAUY)3. Antibodies against NOVA-1 occur in paraneoplastic opsoclonus-ataxia (POA).;

GenBank Accession Number : U04840;

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11/05/2024


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