Dexmedetomidine

Preferred Label : Dexmedetomidine;

NCIt synonyms : ( )-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole;

NCIt definition : An imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord.;

UNII : 67VB76HONO;

InChIKey : CUHVIMMYOGQXCV-NSHDSACASA-N;

CAS number : 113775-47-6;

Chemical formula : C13H16N2;

ChEBI ID : CHEBI:4466;

Details

Origin ID

C47479;

UMLS CUI

C0113293;

Automatic exact mappings (from CISMeF team)
- medetomidine [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dexmedetomidine (substance) [SNOMED CT concept]
- Product containing dexmedetomidine (medicinal product) [SNOMED CT concept]
- dexmedetomidine [ATC Code]
- dexmedetomidine [MeSH concept]
- dexmedetomidine [MeSH Descriptor]
Validated automatic mappings to BTNT
- dexmedetomidine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Dexmedetomidine Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Dexmedetomidine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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