Dexmedetomidine Hydrochloride

Preferred Label : Dexmedetomidine Hydrochloride;

NCIt definition : The hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis.;

UNII : 1018WH7F9I;

InChIKey : VPNGEIHDPSLNMU-MERQFXBCSA-N;

CAS number : 145108-58-3;

Drug name : Precedex;

Chemical formula : C13H16N2.HCl;

ChEBI ID : CHEBI:31472;

PubMed : 9227530;

Details

Origin ID

C72738;

UMLS CUI

C0752310;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dexmedetomidine Hydrochloride [MeSH concept]
- Dexmedetomidine hydrochloride (substance) [SNOMED CT concept]
- dexmedetomidine hydrochloride [International Nonproprietary Name]
Validated automatic mappings to NTBT
- dexmedetomidine [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Dexmedetomidine [NCIt concept]
is_salt_form_of
- Dexmedetomidine [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients