Diazooxonorleucine

Preferred Label : Diazooxonorleucine;

NCIt synonyms : 6-diazo-5-oxo-norleucine; 6-diazo-5-oxo-L-norleucine; DON;

NCIt definition : An L-glutamine diazo analogue amino acid antibiotic isolated from a species of the bacterial genus Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways involved in the syntheses of D-glucosamine phosphate, purines and pyrimidines. This agent inhibits phosphate-activated glutaminase, a key enzyme for the synthesis of releasable glutamine, depleting cells of this essential amino acid and reducing their capacity to proliferate.;

UNII : 03J0H273KZ;

CAS number : 157-03-9;

NSC code : 7365;

Codes from synonyms : NSC0083700; NSC0007365;

Détails

Origin ID

C427;

UMLS CUI

C0012020;

Automatic exact mappings (from CISMeF team)
- DONS [MeSH concept]
- DONS [MeSH Supplementary Concept]
- dysbaric osteonecrosis [DO Concept]
Currated CISMeF NLP mapping
- diazooxonorleucine [MeSH Descriptor]
- diazooxonorleucine [MeSH concept]
See also inter- (CISMeF)
- 6-diazo-5-oxonorleucine [MeSH Supplementary Concept]
- 6-diazo-5-oxonorleucine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- diazooxonorleucine [MeSH concept]
- diazooxonorleucine [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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