Synaptic Vesicle Endocytosis Pathway

Preferred Label : Synaptic Vesicle Endocytosis Pathway;

NCIt synonyms : Endocytosis Pathway;

NCIt related terms : SVE Pathway; Endocytotic role of NDK, Phosphins and Dynamin;

Alternative definition : BIOCARTA: Reliable neurotransmitter release requires the presence of sufficient numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) is coordinated by a group of proteins called dephosphins. The current set of seven known dephosphins are nerve terminal proteins with little or no structural homology but satisfy two essential criteria: they are essential for SVE and they are rapidly and coordinately dephosphorylated in response to a calcium influx through voltage-dependent calcium channels. The calcium signal is mediated by calmodulin (CaM) and calcineurin. Each dephosphin plays an essential role in overlapping phases or segments of the cycle. The four phases of SVE are nucleation, invagination, fission and uncoating. The nucleation phase initiates with the activation of CaM/Calcineurin and the subsequent dephosphorylation of AP180. AP180 and clathrin are then recruited to the membrane by AP2 and PtdIns(4,5)P2. Nucleation is completed by the addition of epsin and eps15. Invagination proceeds with the formation of the amphiphysin1/2 heterodimer and its addition to the maturing vesicle surface complexes. The final components, dynamin and synaptojanin, are recruited to the budding vesicle by the amphiphysin1/2 heterodimer. Dynamin forms a complete ring around the vesicle neck and completes fission via its PtdIns(4,5)P2 stimulated GTPase activity. After internalization the vesicle is quickly uncoated, in a process believed to be mediated by synaptojanin, and is accompanied by the disassembly of clathrin. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ndkDynaminPathway;

Details

Origin ID

C39161;

UMLS CUI

C1516852;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Epidermal Growth Factor Receptor Pathway Substrate 15 [NCIt concept]
- Nucleoside Diphosphate Kinase A [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
pathway_has_gene_element
- EPS15 wt Allele [NCIt concept]
- NME1 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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