" /> NME1 wt Allele - CISMeF





Preferred Label : NME1 wt Allele;

NCIt synonyms : NM23; Nonmetastatic Protein 23 Gene; Non-Metastatic Cells 1, Protein (NM23A) Expressed In wt Allele; NDPKA; NM23 Gene; Nucleoside Diphosphate Kinase-A Gene; NM23H1; NM23-H1;

NCIt definition : Human NME1 wild-type allele is located in the vicinity of 17q21.3 and is approximately 9 kb in length. This allele, which encodes nucleoside diphosphate kinase A protein, is involved in the synthesis of three nucleoside triphosphates (CTP, GTP and UTP). A certain allelic variant of the NME1 gene is associated with advanced stage neuroblastoma.;

NCIt note : The NME1 gene produces two mRNA transcripts via alternative splicing which, in turn, encode distinct isoforms of diphosphate kinase A protein. Expression of the NME1 gene is down-regulated in tumor cells of high metastatic potential.;

GenBank Accession Number : NM_000269;

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28/04/2024


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