Protein Translation Pathway

Preferred Label : Protein Translation Pathway;

NCIt related terms : Eukaryotic protein translation;

Alternative definition : BIOCARTA: The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5' end of the mRNA near the cap. The 48S subunit moves along the mRNA until it finds the initiation triplet and in complex with tRNA and 60S subunit forms the first peptide bond. Translation control is mostly regulated at the protein initiation step through translation initiation factors such as eIF2 or eIF4. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_eifPathway;

Details

Origin ID

C39063;

UMLS CUI

C1514567;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Arylamine N-Acetyltransferase 1 [NCIt concept]
- Elongation Factor 2 [NCIt concept]
- Eukaryotic Elongation Factor 2 Kinase [NCIt concept]
- Eukaryotic Initiation Factor 4A-II [NCIt concept]
- Eukaryotic Translation Initiation Factor 1 [NCIt concept]
- Eukaryotic Translation Initiation Factor 1A, X-Chromosomal [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E [NCIt concept]
- Eukaryotic Translation Initiation Factor 5 [NCIt concept]
pathway_has_gene_element
- EEF2 wt Allele [NCIt concept]
- EEF2K wt Allele [NCIt concept]
- EIF1 wt Allele [NCIt concept]
- EIF1AX wt Allele [NCIt concept]
- EIF4A2 wt Allele [NCIt concept]
- EIF4E wt Allele [NCIt concept]
- EIF5 wt Allele [NCIt concept]
- NAT1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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