Voltage-Dependent Anion-Selective Channel Protein 1

Preferred Label : Voltage-Dependent Anion-Selective Channel Protein 1;

NCIt synonyms : Porin 31HL; Voltage-Dependent Anion-Selective Channel Protein-1; Outer Mitochondrial Membrane Protein Porin-1; Porin; VDAC-1; hVDAC1; Porin 31HM; Plasmalemmal Porin; Voltage-Dependent Anion Channel-1; Outer Mitochondrial Membrane Protein Porin 1;

NCIt definition : Voltage-dependent anion-selective channel protein 1 (283 aa, 31 kDa) is encoded by the human VDAC1 gene. This protein plays a role in the regulation of cell volume, the modulation of apoptosis and the permeability of the outer mitochondrial membrane.;

NCIt note : In response to apoptotic signal transduction, BCL2 proteins regulate cell death by controlling mitochondrial membrane permeability during apoptosis; BCLXL binds to and closes voltage-dependent anion-selective channel protein 1 (VDAC). Proapoptotic BAX and BAK accelerate VDAC opening, allowing cytochrome C to pass through VDAC, which activates death-driving proteolytic caspases.;

Details

Origin ID

C37292;

UMLS CUI

C1259712;

Currated CISMeF NLP mapping
- Porin [FMA entity]
- Voltage-Dependent anion channel 1 [MeSH Descriptor]
- Voltage-Dependent anion channel 1 [MeSH concept]
- porins [MeSH Descriptor]
- porins [MeSH concept]
OMIM relation
- Voltage-dependent anion channel 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- VDAC1 protein, human [MeSH concept]
- VDAC1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Ion Channel Protein Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
- VDAC1 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Hepatic Tissue [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Ion Channel [NCIt concept]
- Outer Mitochondrial Membrane [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Parkinson's Disease Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients