Growth/Differentiation Factor 15

Preferred Label : Growth/Differentiation Factor 15;

NCIt synonyms : PTGFB; PDF; MIC1; NRG1; Placental Bone Morphogenic Protein; PTGF-Beta; NSAID-Regulated Protein 1; Macrophage Inhibitory Cytokine-1; NSAID-Activated Protein 1; GDF15; Placental TGF-Beta; Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1; NAG1; Prostate Differentiation Factor; Prostate-Derived Factor; GDF-15; NAG-1; Macrophage Inhibitory Cytokine 1; NSAID (Nonsteroidal Anti-Inflammatory Drug)-Activated Protein 1; NSAID-Activated Gene 1 Protein; NRG-1; Macrophage-Inhibiting Cytokine 1; NSAID-Regulated Gene 1 Protein;

NCIt definition : Growth/differentiation factor 15 (308 aa, 34 kDa) is encoded by the human GDF15 gene. This protein plays a role in both tissue differentiation and signal transduction.;

NCIt note : The active form of growth/differentiation factor 15 is produced by a proteolytic processing that removes 194 N-terminal amino acids from the full length precursor protein. (UniProt);

Details

Origin ID

C34026;

UMLS CUI

C1431343;

Currated CISMeF NLP mapping
- growth differentiation factor 15 [MeSH Descriptor]
- growth differentiation factor 15 [MeSH concept]
OMIM relation
- Growth/differentiation factor 15 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GDF15 protein, human [MeSH concept]
- GDF15 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- GDF15 Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
- Transforming Growth Factor-Beta Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
- Transforming Growth Factor [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-GDF15 Monoclonal Antibody AV-380 [NCIt concept]
- Ozekibart [NCIt concept]
- Ponsegromab [NCIt concept]
- Visugromab [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients