NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against human growth/differentiation
factor 15 (GDF-15; macrophage inhibitory cytokine-1; MIC-1; non-steroidal anti-inflammatory
drug-inducible gene-1; NAG-1; placental transforming growth factor-beta; pTGFB; prostate-derived
factor; PDF; placental bone morphogenetic protein; PLAB), with potential anti-cachexic
activity. Upon administration, rilogrotug specifically targets, binds to and inhibits
the activity of GDF-15, a pro-inflammatory cytokine involved in cancer-induced cachexia.
This may prevent or slow the effects of cachexia. GDF-15, a divergent member of the
transforming growth factor-beta (TGF-beta) superfamily of cytokines, is upregulated
in cancer-associated cachexia and immunosuppression in the tumor microenvironment
(TME). It is associated with poor prognosis.;
Semantic type(s)