Preferred Label : Anti-GDF15 Monoclonal Antibody AV-380;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against human growth/differentiation
factor 15 (GDF-15; macrophage inhibitory cytokine-1; MIC-1; non-steroidal anti-inflammatory
drug-inducible gene-1; NAG-1; placental transforming growth factor-beta; pTGFB; prostate-derived
factor; PDF; placental bone morphogenetic protein; PLAB), with potential anti-cachexic
activity. Upon administration, anti-GDF15 monoclonal antibody AV-380 specifically
targets, binds to and inhibits the activity of GDF-15, a pro-inflammatory cytokine
involved in cancer-induced cachexia. This may prevent or slow the effects of cachexia.
GDF-15, a divergent member of the transforming growth factor-beta (TGF-beta) superfamily
of cytokines, is upregulated in cancer-associated cachexia and immunosuppression in
the tumor microenvironment (TME). It is associated with poor prognosis.;
Molecule name : AV-380; AV 380;
Origin ID : C200801;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
