NCIt definition : A monoclonal antibody directed against growth/differentiation factor 15 (GDF-15; macrophage
inhibitory cytokine-1; MIC-1; non-steroidal anti-inflammatory drug-inducible gene-1;
NAG-1; placental transforming growth factor-beta; pTGFB; prostate-derived factor;
PDF; placental bone morphogenetic protein; PLAB), with potential antineoplastic activity.
Upon administration, anti-GDF-15 monoclonal antibody AZD8853 specifically targets,
binds to and inhibits the activity of GDF-15, thereby preventing the GDF-15-mediated
inhibition of differentiation and activation of human monocyte-derived dendritic cells
(DCs) and T-cells. This may restore immune cell infiltration into the tumor, leading
to increases in T-cells and activated DCs in the tumor microenvironment (TME). This
enhances tumor cell killing and inhibits tumor cell proliferation. GDF-15, a divergent
member of the transforming growth factor-beta (TGF-beta) superfamily of cytokines,
is upregulated in tissue injuries and is secreted by various tumors. Upregulation
of GDF-15 is associated with immunosuppression in the TME, drug resistance and poor
prognosis.;
Semantic type(s)