Receptor-Interacting Serine/Threonine-Protein Kinase 3

Preferred Label : Receptor-Interacting Serine/Threonine-Protein Kinase 3;

NCIt synonyms : Receptor-Interacting Protein 3; RIP-Like Protein Kinase 3; RIP3; RIPK3; Receptor-Interacting Serine/Threonine Protein Kinase 3; RIP-3; EC 2.7.11.1; Receptor-Interacting Serine-Threonine Protein Kinase-3;

NCIt definition : Receptor-interacting serine/threonine-protein kinase 3 (518 aa, 57 kDa) is encoded by the human RIPK3 gene. This protein plays a role in the induction of necrosis.;

NCIt note : RIPK3 colocalizes in the mitochondrion with RIPK1. RIPK3 is recruited to the TNFR1 complex in a RIPK1-dependent manner and interacts with TRAF2. The RIPK3 C-terminus is required to induce apoptosis through the activation of some or all caspases and also appears to activate NFKB. RIPK3 can stimulate NFKB nuclear translocation.;

Details

Origin ID

C29873;

UMLS CUI

C1431910;

Currated CISMeF NLP mapping
- Receptor-Interacting protein Serine-Threonine kinase 3 [MeSH concept]
OMIM relation
- Receptor-interacting serine/threonine kinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- RIPK3 protein, human [MeSH concept]
- RIPK3 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RIPK3 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytosolic DNA-Sensing Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients