Geminin - CISMeF

Preferred Label : Geminin;

NCIt definition : Geminin (209 aa, 24 kDa) is encoded by the human GMNN gene. This protein is involved in the modulation of DNA replication.;

NCIt note : Geminin inhibits DNA replication during S, G2, and M phases by sequestering CDT1, a replication initiation factor necessary for MCM loading, to prevent the incorporation of MCM complex into prereplication complex. Geminin has a destruction box sequence (RRTLKVIQP) and is ubiquitinated by the anaphase-promoting complex. Geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Geminin may also inhibit inappropriate origin firing by targeting CDT1. In the normal cell cycle, CDT1 is present only in G1 and S phases, whereas geminin is present in S and G2 phases.;

Details

Origin ID

C29620;

UMLS CUI

C0676272;

Automatic exact mappings (from CISMeF team)
- geminin [MeSH Descriptor]
- geminin [MeSH concept]
OMIM relation
- Geminin dna replication inhibitor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GMNN protein, human [MeSH Supplementary Concept]
- GMNN protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- GMNN Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- DNA Replication Inhibition [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]

Keyword's position in hierarchy(ies) :

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