Generation of Antibody Diversity

Preferred Label : Generation of Antibody Diversity;

NCIt definition : Generation of Antibody Diversity during B-lymphocyte development results from a cascade of temporally ordered random gene shuffling translocations by a recombinase that join any one of multiple alternative discrete V, D, and J (heavy chain) or V and J (light chain) antibody gene variable region DNA coding segments that produce in each B-lymphocyte an antibody with a unique antigen binding region composed of a heavy and a light protein chain. In addition, splicing inaccuracies or insertion of additional nucleotides at the segment junctions generate further junctional diversity and somatic hypermutation of V regions, as B-lymphocytes proliferate, create better fitting antigen-binding sites.;

Details

Origin ID

C26555;

UMLS CUI

C1517502;

Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_involves_gene_product
- DNA Nucleotidylexotransferase [NCIt concept]
biological_process_is_part_of_process
- B-Cell Differentiation [NCIt concept]
process_involves_gene
- DNTT Gene [NCIt concept]
- DNTT wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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