" /> DNA Nucleotidylexotransferase - CISMeF





Preferred Label : DNA Nucleotidylexotransferase;

NCIt synonyms : Terminal Deoxynucleotidyltransferase; TdT; EC 2.7.7.31; Deoxynucleotidyl Terminal Transferase; DNTT; Terminal Deoxyribonucleotidyl Transferase; Terminal Transferase; Terminal Addition Enzyme;

NCIt definition : DNA nucleotidylexotransferase (509 aa, 59 kDa) is encoded by the human DNTT gene. This protein plays a role in DNA polymerization and specifically catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes.;

NCIt note : Terminal deoxynucleotidyltransferase is a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells.;

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29/04/2024


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