Preferred Label : Lymphocyte Cytosolic Protein 2;
NCIt synonyms : 76 kD Tyrosine Phosphoprotein; SLP-76 Tyrosine Phosphoprotein; SLP76; SLP-76; SH2 domain-containing leukocyte protein of 76kD; LCP2 Protein; LCP2; SH2 Domain-Containing Leukocyte Protein, 76kD; Lymphocyte Cytosolic Protein-2;
NCIt definition : Lymphocyte cytosolic protein 2 (533 aa, 60 kDa) is encoded by the human LCP2 gene.
This protein is involved in signal transduction.;
NCIt note : Encoded by human LCP2 Gene and expressed in peripheral leukocytes, spleen, thymus,
T-cells, B-cells, and monocytes, modular 533-amino acid 76-kD adaptor/scaffold Lymphocyte
Cytosolic Protein 2 contains three domains; a PEST domain and phosphorylatable tyrosine
residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich
domain, and a C-terminal SH2 domain. SLP-76 associates constitutively or inducibly
with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting
receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell
development and activation, as well as mast cell and platelet function. SLP-76 may
collect all pre-TCR signals that drive thymocyte development and appears required
for separate development of lymphatic vessels from blood vessels. (from LocusLink,
Swiss-Prot, OMIM, and NCI);
Origin ID : C26347;
UMLS CUI : C1743669;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_plays_role_in_biological_process
