T-Cell Differentiation in the Thymus

Preferred Label : T-Cell Differentiation in the Thymus;

NCIt synonyms : Thymocyte Development;

NCIt definition : The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.;

Details

Origin ID

C19317;

UMLS CUI

C1515432;

Currated CISMeF NLP mapping
- T cell differentiation in thymus [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- T cell differentiation in thymus [GO term]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_has_result_anatomy
- T-Lymphocyte [NCIt concept]
biological_process_involves_gene_product
- Atypical Chemokine Receptor 2 [NCIt concept]
- Lymphocyte Cytosolic Protein 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- Thymocyte Selection-Associated High Mobility Group Box Protein TOX [NCIt concept]
biological_process_is_part_of_process
- Histogenic Process [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Immune System Process [NCIt concept]
process_involves_gene
- ACKR2 Gene [NCIt concept]
- ACKR2 wt Allele [NCIt concept]
- CCL17 Gene [NCIt concept]
- CCL17 wt Allele [NCIt concept]
- CCR9 Gene [NCIt concept]
- CCR9 wt Allele [NCIt concept]
- CD3D Gene [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E Gene [NCIt concept]
- CD3E wt Allele [NCIt concept]
- LCP2 Gene [NCIt concept]
- LCP2 wt Allele [NCIt concept]
- MAPK3 Gene [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- TOX Gene [NCIt concept]
- TOX wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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