Preferred Label : Atypical Chemokine Receptor 2;
NCIt synonyms : CCBP2; hD6; CMBRK9; Chemokine-Binding Protein D6; CC-Chemokine Receptor CCR-10; D6; CC-Chemokine Receptor CCR-9; C-C Chemokine Receptor D6; CC-Chemokine-Binding Receptor JAB61; C-C Motif Chemokine Receptor-9; Chemokine-Binding Protein 2; ACKR2;
NCIt definition : Atypical chemokine receptor 2 (384 aa, 43 kDa) is encoded by the human ACKR2 gene.
This protein is involved in the downregulation of chemokine signaling.;
NCIt note : Expressed in placenta, lung, lymphatic endothelia, lymph nodes, intestinal mucosa/submucosa,
hemopoietic cells, and fetal liver by human CCBP2 Gene (GPCR1/Beta Chemokine Receptor
Family), Chemokine (C-C Motif) Receptor 9 is a seven transmembrane G protein-coupled
receptor for many beta chemokines (MCP1, MIP1-alpha, RANTES, MCP3) and is critical
for recruitment of effector immune cells to inflammation sites. CCBP2 does not mediate
intracellular calcium flux but may function in chemokine-driven recirculation of leukocytes.; Chemokine-Binding Protein 2, product of human CCBP2 Gene at 3p21.3, is not equivalent
to C-C Chemokine Receptor Type 9, product of human CCR9 Gene at 3p21.3.;
Origin ID : C25781;
UMLS CUI : C1872960;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
