Adhesion G Protein-Coupled Receptor B1

Preferred Label : Adhesion G Protein-Coupled Receptor B1;

NCIt synonyms : BAI1; Brain-Specific Angiogenesis Inhibitor 1; Brain-Specific Angiogenesis Inhibitor-1; ADGRB1;

NCIt definition : Adhesion G protein-coupled receptor B1 (1584 aa, 174 kDa) is encoded by the human ADGRB1 gene. This protein is involved in G protein-coupled receptor signaling and the inhibition of angiogenesis.;

NCIt note : BAI1 is a a seven-span transmembrane protein and is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. (LocusLink);

Details

Origin ID

C26145;

UMLS CUI

C1332603;

OMIM relation
- Adhesion g protein-coupled receptor b1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- ADGRB1 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Angiogenesis Inhibitory Protein [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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