D(1B) Dopamine Receptor

Preferred Label : D(1B) Dopamine Receptor;

NCIt synonyms : DBDR; Dopamine Receptor D1B; D(5) Dopamine Receptor; DRD1B; Dopamine D5 Receptor; D1Beta Dopamine Receptor; DRD5; Dopamine Receptor D5; DRD1L2; Dopamine Receptor-D5;

NCIt definition : D(1B) dopamine receptor (477 aa, 53 kDa) is encoded by the human DRD5 gene. This protein plays a role in dopaminergic synaptic transmission and adenylate cyclase activation.;

NCIt note : Dopamine Receptor D5, encoded by the human DRD5 gene, is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. This receptor complexes selectively with GABA-A ligand-gated channel through the direct binding of its carboxy-terminal domain with the second intracellular loop of the GABA-A gamma-2 (short) receptor subunit. This physical association enables mutual inhibitory functional interactions between these receptor systems. Pseudogenes related to this gene reside on chromosomes 1 and 2. Defects in DRD5 are a cause of blepharospasm, a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age.;

Details

Origin ID

C26122;

UMLS CUI

C1529472;

Currated CISMeF NLP mapping
- Dopamine receptor D5 [OMIM Phenotype]
- Dopamine receptor D5 [ORDO Gene]
- receptors, dopamine D5 [MeSH concept]
- receptors, dopamine d5 [MeSH Descriptor]
OMIM relation
- Dopamine receptor D5 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- DRD5 protein, human [MeSH Supplementary Concept]
- DRD5 protein, human [MeSH concept]
- receptors, dopamine D5 [MeSH concept]
- receptors, dopamine d5 [MeSH Descriptor]
gene_encodes_gene_product
- DRD5 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Neuron [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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