Pegylated Interferon Alfa

Preferred Label : Pegylated Interferon Alfa;

NCIt synonyms : PEG-interferon alfa; PEG-IFN-a;

NCIt definition : A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04);

Details

Origin ID

C2491;

UMLS CUI

C0907160;

Automatic exact mappings (from CISMeF team)
- Interferon alfa [SMS substance]
- Interferon alpha [LOINC component]
- interferon-alpha [MeSH Descriptor]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Autologous Lymphocytes/Fluorouracil/Pegylated Interferon Alfa/Sargramostim [NCIt concept]
- Pegylated Interferon Alfa/Temozolomide [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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