NCIt definition : A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine
irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis,
thereby inhibiting the formation and proliferation of tumor cells. Polyamines are
involved in nucleosome oligomerization and DNA conformation, creating a chromatin
environment that stimulates neoplastic transformation of cells. This agent has been
shown to induce apoptosis in leiomyoma cells. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the prevention of cancer. It belongs
to the family of drugs called antiprotozoals.;
UNII : ZQN1G5V6SR;
InChIKey : VLCYCQAOQCDTCN-UHFFFAOYSA-N;
CAS number : 70052-12-9; 67037-37-0;
Chemical formula : C6H12F2N2O2;
ChEBI ID : CHEBI:41948;
Codes from synonyms : CDR0000044390; CDR0000045984; CDR0000045255; 135220;