Eflornithine - CISMeF

Preferred Label : Eflornithine;

NCIt synonyms : 2-(Difluoromethyl)-DL-ornithine; Difluoromethylornithine; Difluromethylornithine; DFMO; Alpha-Difluoromethylornithine; D,L-alpha-Difluoromethylornithine; 2-Difluoromethylornithine;

NCIt definition : A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.;

UNII : ZQN1G5V6SR;

InChIKey : VLCYCQAOQCDTCN-UHFFFAOYSA-N;

CAS number : 70052-12-9; 67037-37-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 70052-12-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 67037-37-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C6H12F2N2O2;

ChEBI ID : CHEBI:41948;

Codes from synonyms : CDR0000044390; CDR0000045984; CDR0000045255;

Details

Origin ID

C226;

UMLS CUI

C0002260;

See also inter- (CISMeF)
- Product containing eflornithine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Eflornithine [ICD-11 Extension code]
- Eflornithine (substance) [SNOMED CT concept]
- Product containing eflornithine (medicinal product) [SNOMED CT concept]
- eflornithine [ATC Code]
- eflornithine [ATC Code]
- eflornithine [MeSH concept]
- eflornithine [MeSH Descriptor]
Validated automatic mappings to BTNT
- eflornithine [ATC Code]
- eflornithine [ATC Code]
chemical_or_drug_affects_gene_product
- Ornithine Decarboxylase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Polyamine Synthesis Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Eflornithine Hydrochloride [NCIt concept]
has_target
- Ornithine Decarboxylase [NCIt concept]
is_component_of_chemotherapy_regimen
- Celecoxib/Eflornithine [NCIt concept]
- Doxorubicin/eflornithine/Interferon Alfa [NCIt concept]
- Eflornithine/Interferon Alfa [NCIt concept]
- Eflornithine/Lomustine/Procarbazine/Vincristine [NCIt concept]
- Eflornithine/Mitoguazone [NCIt concept]
- Eflornithine/Piroxicam [NCIt concept]
- Eflornithine/Sulindac [NCIt concept]
- Eflornithine/Triamcinolone [NCIt concept]
is_free_acid_or_base_form_of
- Eflornithine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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