" /> Eflornithine Hydrochloride - CISMeF





Preferred Label : Eflornithine Hydrochloride;

NCIt synonyms : 2-(Difluoromethyl)-dl-ornithine Hydrochloride, Monohydrate; 2-Difluoromethyl-dl-ornithine, Monohydrochloride, Monohydrate; alpha-Difluoromethylornithine hydrochloride;

NCIt related terms : Eflornithine.HCl;

NCIt definition : The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. (NCI04);

UNII : 4NH22NDW9H;

InChIKey : FJPAMFNRCFEGSD-UHFFFAOYSA-N;

CAS number : 96020-91-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 96020-91-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Ornidyl; Vaniqa; Iwilfin;

Molecule name : RMI-71782; MDL 71782;

Chemical formula : C6H12F2N2O2.HCl.H2O;

NSC code : 270295; 337250;

Codes from synonyms : NSC0337250; 20059;

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12/05/2024


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