Transcription Activator BRG1

Preferred Label : Transcription Activator BRG1;

NCIt synonyms : Possible Global Transcription Activator SNF2L4; SNF2-Beta; BRG1 Protein; BAF190A; BRG-1 Protein Mitotic Growth and Transcription Activator; BRG-1/SNF2beta; SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4; SNF2beta; Protein Brahma Homolog 1; SMARCA4; BRG1; BRG-1; Mitotic Growth and Transcription Activator; Brahma Protein Homolog 1; BRG1-Associated Factor 190A; Protein BRG-1; ATP-Dependent Helicase SMARCA4; BRM/SWI2-Related Protein 1; SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin Subfamily A Member 4;

NCIt definition : Transcription activator BRG1 (1647 aa, 185 kDa) is encoded by the human SMARCA4 gene. This protein plays a role in the mediation of both chromatin remodeling and transcription.;

NCIt note : Transcription activator BRG1 is an SNF2/RAD54 helicase family member and ATPase subunit of the SWI/SNF enzyme complex.;

Details

Origin ID

C19845;

UMLS CUI

C0248587;

OMIM relation
- Swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SMARCA4 protein, human [MeSH Supplementary Concept]
- SMARCA4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SMARCA4 Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
gene_product_has_chemical_classification
- SWI2/SNF2 Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Bromodomain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Gene Expression Regulation by Vitamin D Receptor Pathway [NCIt concept]
- hSWI-SNF Pathway [NCIt concept]
gene_product_is_physical_part_of
- Canonical BAF Complex [NCIt concept]
- E-RC1 [NCIt concept]
- Neural Progenitor-Specific BAF Complex [NCIt concept]
- Neuron-Specific BAF Complex [NCIt concept]
- Non-Canonical BAF Complex [NCIt concept]
- PBAF Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- BRG1/BRM Inhibitor FHD-286 [NCIt concept]

Keyword's position in hierarchy(ies) :

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