Preferred Label : DDR1-2/VEGFR2-3/PDGFRalpha-beta Inhibitor ICP-033;
NCIt synonyms : RTK Inhibitor ICP-033;
NCIt definition : An orally bioavailable inhibitor of multiple receptor tyrosine kinases (RTKs), with
potential antineoplastic activity. Upon oral administration, DDR1-2/VEGFR2-3/PDGFRalpha-beta
inhibitor ICP-033 selectively targets, binds to and inhibits the activity of numerous
RTKs including discoid domain receptor type 1 (DDR1) and 2 (DDR2), vascular endothelial
growth factor receptors type 2 (VEGFR2) and 3 (VEGFR3) and platelet-derived growth
factor receptor alpha (PDGFRa) and beta (PDGFRb). By inhibiting multiple RTKs located
in endothelial cells, pericytes and stroma, ICP-033 may be able to inhibit angiogenesis
and tumor cell invasion, normalize abnormal blood vessels, and reverse the immunosuppressive
state of the tumor microenvironment (TME). This may halt tumor cell proliferation
in susceptible tumor cells.;
Molecule name : ICP 033; ICP-033;
NCI Metathesaurus CUI : CL1792375;
Origin ID : C187694;
UMLS CUI : C5706436;
Semantic type(s)
- concept_is_in_subset
- has_target
