Discoidin Domain-Containing Receptor 2

Preferred Label : Discoidin Domain-Containing Receptor 2;

NCIt synonyms : DDR2; NTRKR3; Neurotrophic Tyrosine Kinase Receptor-Related 3; Tyrosine Kinase Receptor Related to Neurotrophic TRK; TKT; Neurotrophic Tyrosine Kinase, Receptor-Related 3; DDR2 Protein; Discoidin Domain Receptor Family Member 2; TYRO10; Receptor Protein-Tyrosine Kinase TKT; CD167 Antigen-Like Family Member B; Discoidin Domain Receptor 2; CD167b; EC 2.7.10.1; Antigen CD167b; Discoidin Domain-Containing Receptor Tyrosine Kinase 2; CD167b Antigen; Discoidin Domain Receptor-2; Tyrosine-Protein Kinase TYRO10;

NCIt definition : Discoidin domain-containing receptor 2 (855 aa, 97 kDa) is encoded by the human DDR2 gene. This protein plays a role in environment-to-cell communication, protein phosphorylation, extracellular matrix remodeling and differentiation of both osteoclasts and chondrocytes.;

Details

Origin ID

C26211;

UMLS CUI

C3853571;

Currated CISMeF NLP mapping
- discoidin domain receptor 2 [MeSH concept]
OMIM relation
- Discoidin domain receptor family, member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- DDR2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Heart [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Lung [NCIt concept]
- Pancreas [NCIt concept]
- Placenta [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- DDR2 NP_001014796.1:p.I638F [NCIt concept]
- DDR2 NP_001014796.1:p.L239R [NCIt concept]
- DDR2 NP_001014796.1:p.R742W [NCIt concept]
- DDR2 NP_001014796.1:p.S768R [NCIt concept]
- DDR2 Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- DDR1-2/VEGFR2-3/PDGFRalpha-beta Inhibitor ICP-033 [NCIt concept]

Keyword's position in hierarchy(ies) :

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